You discover a family with a history of Leigh syndrome, a disease where affected individuals have a rapid decline in physiological function. Leigh syndrome originates from defects in mitochondrial oxidative phosphorylation. Based on the pedigree results shown below, what is the most likely cause of the disease?

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Violence

Violence is defined as a physical act that causes or is intended to cause harm. Violence can cause physical, emotional, or both types of harm. Violence is defined by the World Health Organization as the intended use of physical force and power that causes threat or harm against oneself, another person, or against a community or group, and has the potential to cause damage, death, mental distress, maldevelopment, or poverty.