HOMEWORK: Tonicity Calculations- Make the following prescriptions isotonic: Use sodium chloride equivalent method and freezing point depression method for each problem. 1. Ephedrine sulfate Sodium chloride Purified water Sig: Use as directed. 0.3g q.s ad 30 mL Ephedrine sulfate: E = 0.23, ΔTf 1%=0.13 Sodium chloride: ΔTf 1%= 0.58 2. Dipivefrin HCl Scopolomine HBr Sodium chloride Purified water Sig: Use in the eye ½ % ⅓ % q.s ad 30 mL Dipivefrin HCl: E = 0.17, ΔTf 1%=0.09 Scopolomine HBr: E = 0.12, ΔTf 1%=0.06 3. Zinc sulfate, 7H2O Boric acid Purified water Sig: Use as directed 0.06 q.s ad 30 mL Zinc sulfate, 7H2O: E = 0.15, ΔTf 1%=0.08 Boric acid: E = 0.50, ΔTf 1%=0.29 4. Cromolyn sodium Benzalkonium chloride 4% 1:10,000 (w/v) Buffer (pH = 5.6, E = 0.30) q.s Water for injection ad 10 mL Sig: One drop in each eye b.i.d. Cromolyn sodium: E = 0.15, ΔTf 1%=0.08 Benzalkonium chloride: E = 0.16, ΔTf 1%=0.09 5. Cocaine HCl Eucatropine HCl Chlorbutanol Sodium chloride Purified water Sig: Use as directed 0.6 g 0.6 g 0.1 g q.s ad 30 mL Cocaine HCl: E = 0.16, ΔTf 1%=0.09 Eucatropine HCl: E = 0.18, ΔTf 1%=0.11 Chlorbutanol: E = 0.24, ΔTf 1%=0.14 6. Homatropine HBr 1% 15 mL Make isotonic with Boric acid. Sig: For the eye. Homatropine HBr: E = 0.17, ΔTf 1%=0.09
HOMEWORK: Tonicity Calculations- Make the following prescriptions isotonic: Use sodium chloride equivalent method and freezing point depression method for each problem.
1. Ephedrine sulfate Sodium chloride Purified water Sig: Use as directed. 0.3g q.s ad 30 mL Ephedrine sulfate: E = 0.23, ΔTf 1%=0.13 Sodium chloride: ΔTf 1%= 0.58
2. Dipivefrin HCl Scopolomine HBr Sodium chloride Purified water Sig: Use in the eye ½ % ⅓ % q.s ad 30 mL Dipivefrin HCl: E = 0.17, ΔTf 1%=0.09 Scopolomine HBr: E = 0.12, ΔTf 1%=0.06
3. Zinc sulfate, 7H2O Boric acid Purified water Sig: Use as directed 0.06 q.s ad 30 mL Zinc sulfate, 7H2O: E = 0.15, ΔTf 1%=0.08 Boric acid: E = 0.50, ΔTf 1%=0.29
4. Cromolyn sodium Benzalkonium chloride 4% 1:10,000 (w/v) Buffer (pH = 5.6, E = 0.30) q.s Water for injection ad 10 mL Sig: One drop in each eye b.i.d. Cromolyn sodium: E = 0.15, ΔTf 1%=0.08 Benzalkonium chloride: E = 0.16, ΔTf 1%=0.09
5. Cocaine HCl Eucatropine HCl Chlorbutanol Sodium chloride Purified water Sig: Use as directed 0.6 g 0.6 g 0.1 g q.s ad 30 mL Cocaine HCl: E = 0.16, ΔTf 1%=0.09 Eucatropine HCl: E = 0.18, ΔTf 1%=0.11 Chlorbutanol: E = 0.24, ΔTf 1%=0.14
6. Homatropine HBr 1% 15 mL Make isotonic with Boric acid. Sig: For the eye. Homatropine HBr: E = 0.17, ΔTf 1%=0.09
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