Histidine is an important catalytic residue found at the active sites of many enzymes. In many cases, histidine appears toremove protons or to transfer protons from one location to another.(a) Show which nitrogen atom of the histidine heterocycle is basic and which is not.(b) Use resonance forms to show why the protonated form of histidine is a particularly stable cation.(c) Show the structure that results when histidine accepts a proton on the basic nitrogen of the heterocycle and then isdeprotonated on the other heterocyclic nitrogen. Explain how histidine might function as a pipeline to transfer protonsbetween sites within an enzyme and its substrate
Histidine is an important catalytic residue found at the active sites of many enzymes. In many cases, histidine appears toremove protons or to transfer protons from one location to another.(a) Show which nitrogen atom of the histidine heterocycle is basic and which is not.(b) Use resonance forms to show why the protonated form of histidine is a particularly stable cation.(c) Show the structure that results when histidine accepts a proton on the basic nitrogen of the heterocycle and then isdeprotonated on the other heterocyclic nitrogen. Explain how histidine might function as a pipeline to transfer protonsbetween sites within an enzyme and its substrate
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
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Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Histidine is an important catalytic residue found at the active sites of many enzymes. In many cases, histidine appears to
remove protons or to transfer protons from one location to another.
(a) Show which nitrogen atom of the histidine heterocycle is basic and which is not.
(b) Use resonance forms to show why the protonated form of histidine is a particularly stable cation.
(c) Show the structure that results when histidine accepts a proton on the basic nitrogen of the heterocycle and then is
deprotonated on the other heterocyclic nitrogen. Explain how histidine might function as a pipeline to transfer protons
between sites within an enzyme and its substrate
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