Hemoglobin – Answer 1 question from this block. 8. Lack of 2,3-BPG can be deadly. A) What is 2,3-BPG? How is it produced and why does hemoglobin need 2,3- BPG? B) Under what physiological conditions are blood levels of 2,3-BPG elevated? C) How does an increased level of 2,3-BPG help our bodies compensate through crises of a low availability of external oxygen? Highlight the action of 2,3-BPG on hemoglobin in your answer.

Biochemistry
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Chapter1: Biochemistry: An Evolving Science
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**Hemoglobin – Answer 1 question from this block.**

8. Lack of 2,3-BPG can be deadly.

A) What is 2,3-BPG? How is it produced and why does hemoglobin need 2,3-BPG?

B) Under what physiological conditions are blood levels of 2,3-BPG elevated?

C) How does an increased level of 2,3-BPG help our bodies compensate through crises of a low availability of external oxygen? Highlight the action of 2,3-BPG on hemoglobin in your answer.

---

**Diagram Explanation:**

The graph provided plots the partial pressure of oxygen (pO₂) in kilopascals (kPa) against the fraction of oxygen-saturated hemoglobin (Y). There are three curves representing different concentrations of 2,3-BPG:

1. **Black Curve (BPG = 0 mM):** This shows the highest affinity of hemoglobin for oxygen, meaning oxygen binds strongly to hemoglobin.

2. **Green Curve (BPG = 5 mM at sea level):** This represents the typical physiological condition, with a moderate binding affinity.

3. **Blue Curve (BPG = 8 mM at high altitudes, 4,500 m):** This illustrates a lower affinity for oxygen, indicating that hemoglobin releases oxygen more readily to tissues.

Vertical lines indicate oxygen partial pressures in tissues and lungs at sea level and high altitudes:
- **pO₂ in tissues (~4 kPa)**
- **pO₂ in lungs at 4,500 m (~7 kPa)**
- **pO₂ in lungs at sea level (~13 kPa)**

The graph shows that as 2,3-BPG levels increase, hemoglobin's affinity for oxygen decreases, facilitating oxygen release to tissues.
Transcribed Image Text:**Hemoglobin – Answer 1 question from this block.** 8. Lack of 2,3-BPG can be deadly. A) What is 2,3-BPG? How is it produced and why does hemoglobin need 2,3-BPG? B) Under what physiological conditions are blood levels of 2,3-BPG elevated? C) How does an increased level of 2,3-BPG help our bodies compensate through crises of a low availability of external oxygen? Highlight the action of 2,3-BPG on hemoglobin in your answer. --- **Diagram Explanation:** The graph provided plots the partial pressure of oxygen (pO₂) in kilopascals (kPa) against the fraction of oxygen-saturated hemoglobin (Y). There are three curves representing different concentrations of 2,3-BPG: 1. **Black Curve (BPG = 0 mM):** This shows the highest affinity of hemoglobin for oxygen, meaning oxygen binds strongly to hemoglobin. 2. **Green Curve (BPG = 5 mM at sea level):** This represents the typical physiological condition, with a moderate binding affinity. 3. **Blue Curve (BPG = 8 mM at high altitudes, 4,500 m):** This illustrates a lower affinity for oxygen, indicating that hemoglobin releases oxygen more readily to tissues. Vertical lines indicate oxygen partial pressures in tissues and lungs at sea level and high altitudes: - **pO₂ in tissues (~4 kPa)** - **pO₂ in lungs at 4,500 m (~7 kPa)** - **pO₂ in lungs at sea level (~13 kPa)** The graph shows that as 2,3-BPG levels increase, hemoglobin's affinity for oxygen decreases, facilitating oxygen release to tissues.
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