Which of the following concerning hemoglobin is true? a) BPG decreases at high altitudes and causes more O2 offloading in tissues b) As pH increases, [CO2] increases in tissues, causing more O2 release in tissue c) The R state is stabilized by CO2 binding, whereas the T state is stabilized by O2 binding d) About 38% of oxygen dissociates from hemoglobin in tissues e) Hemoglobin has a higher affinity for oxygen than carbon monoxide My guess is D. What following statement is TRUE concerning motifs and domains? a) Both motifs and domains are independently stable. b) Domains undergo dynamic individual changes that affect the entire protein c) B-a-ß loops, B barrels, and helix-turn-helix structure are types of domains d) Motifs and domains are part of secondary structural elements e) Ab initio computations predict motif folds accurately a majority of the time My guess is B. Which of the following is TRUE under the following conditions: an enzyme displaying Michaelis-Menten kinetics where the enzyme concentration is 10 nM, substrate concentration is 45 uM, and the KM = 50 M? a) The enzymatic reaction is near maximal velocity b) Halving the substrate concentration has little effect on the catalytic rate c) The rate of catalysis is near half-maximal velocity d) The enzyme has low catalytic efficiency for the substrate e) There is not enough information provided
Which of the following concerning hemoglobin is true?
a) BPG decreases at high altitudes and causes more O2 offloading in tissues
b) As pH increases, [CO2] increases in tissues, causing more O2 release in tissue
c) The R state is stabilized by CO2 binding, whereas the T state is stabilized by O2 binding
d) About 38% of oxygen dissociates from hemoglobin in tissues
e) Hemoglobin has a higher affinity for oxygen than carbon monoxide
My guess is D.
What following statement is TRUE concerning motifs and domains?
a) Both motifs and domains are independently stable.
b) Domains undergo dynamic individual changes that affect the entire protein
c) B-a-ß loops, B barrels, and helix-turn-helix structure are types of domains
d) Motifs and domains are part of secondary structural elements
e) Ab initio computations predict motif folds accurately a majority of the time
My guess is B.
Which of the following is TRUE under the following conditions: an enzyme displaying Michaelis-Menten kinetics where the enzyme concentration is 10 nM, substrate concentration is 45 uM, and the KM = 50 M?
a) The enzymatic reaction is near maximal velocity
b) Halving the substrate concentration has little effect on the catalytic rate
c) The rate of catalysis is near half-maximal velocity
d) The enzyme has low catalytic efficiency for the substrate
e) There is not enough information provided
My guess is C.
1
Hemoglobin is a globular protein, i.e. it is roughly spherical. It is an oxygen-binding protein that has a protein part called globin and a heme prosthetic group. It binds to oxygen cooperativity in the lungs and unbinds oxygen in tissue. It can also transport H+ and CO2.
2
Motifs and domains are supersecondary structures found in protein. They are made up of secondary structure elements like an alpha helix, beta sheets and beta turns. Motifs are mostly structural features but the domain serves a functional role.
3
For enzymes that follow Michaelis-Menten kinetics, the initial rate of reaction can be calculated using the Michaelis-Menten equation:
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