1. Sketch out a graph showing the proposed relationship between pH and bacterial infection in people with CF. 2. What reasoning is provided that explains the relationship between pH and infection rate in people with CF?
1. Sketch out a graph showing the proposed relationship between pH and bacterial infection in people with CF. 2. What reasoning is provided that explains the relationship between pH and infection rate in people with CF?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Bicarbonate (HCO3) also moves through the CFTR protein into the fluid lining the airway. People with CF
cannot move HCO3 as effectively, which causes the pH of the fluid lining the airway to become more acidic. A
lower pH of the airway fluid has been shown to impact the ability of immune cells to function properly and may
explain why people with CF have high rates of bacterial infections. This relationship between HCO3, pH, and
infection is still being investigated and is not totally understood or agreed upon by scientists.
Normal CFTR Airway
Chloride
Bicarbonate
Mutated CFTR Airway
Chloride
Bicarbonate
Water
María Macarena Massip-Copiz, Tomás Antonio Santa-Coloma. Extracellular pH and lung infections in cystic fibrosis. European Journal of Cell Biology
Volume 97, Issue 6. 2018. Pages 402-410. https://doi.org/10.1016/j.eicb 2018.06.001.
1. Sketch out a graph showing the proposed relationship between pH and bacterial infection in people
with CF.
2. What reasoning is provided that explains the relationship between pH and infection rate in people with
CF?
11
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