Give an brief explanation: A 69-year-old male is preparing to undergo a lung transplant. The transplantation laboratory is playing a major role in the preparations by consulting with the surgical team performing the transplant. 1. Members of the transplant team, including the transplantation laboratory, discuss the risk of graft-versus-host disease (GVHD) associated with lung transplantation. What is GVHD? A, Recipient T cells recognize foreign HLA antigens on donor cells, activating CD8 T cytotoxic cells. B. Recipient antigen-presenting cells receive processed donor HLA peptides from recipient HLA Class II molecules, which cause CD4 T helper cells to activate B cells to produce antibodies to foreign HLA molecules. C. Transplanted lymphocytes mount an immune response toward the recipient through T-cell destruction of host tissue. 2. Why does lung tissue have an increased risk of GVHD? A. Lung tissue is hard to properly match for ABO. B. Lung tissue contains an increased number of neutrophils. C. Lung tissue contains increased amounts of lymphoid cells capable of inducing an immune response.
Give an brief explanation:
A 69-year-old male is preparing to undergo a lung transplant. The transplantation laboratory is playing a major role in the preparations by consulting with the surgical team performing the transplant.
1. Members of the transplant team, including the transplantation laboratory, discuss the risk of graft-versus-host disease (GVHD) associated with lung transplantation. What is GVHD?
A, Recipient T cells recognize foreign HLA antigens on donor cells, activating CD8 T cytotoxic cells.
B. Recipient antigen-presenting cells receive processed donor HLA peptides from recipient HLA Class II molecules, which cause CD4 T helper cells to activate B cells to produce antibodies to foreign HLA molecules.
C. Transplanted lymphocytes mount an immune response toward the recipient through T-cell destruction of host tissue.
2. Why does lung tissue have an increased risk of GVHD?
A. Lung tissue is hard to properly match for ABO.
B. Lung tissue contains an increased number of neutrophils.
C. Lung tissue contains increased amounts of lymphoid cells capable of inducing an immune response.
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