QUESTION 1 A. Define equilibrium constant of a drug B. Discuss the relationship between the equilibrium constant, affinity, potency and the response of a drug C. Discuss four factors that may affect a drug response
Q: d. What type of inhibition is exhibited against NAD* as a cofactor? Describe what is going on in…
A: Any parameter of enzyme catalyzed reaction such as Vmax and Km can be obtained from Lineweaver Bur…
Q: A patient is receiving radiation to the chest. The calculated dose to the tumor while "on cord" is…
A: According to the linear-quadratic model: To know the different biological effects of different…
Q: Which of the following adverse drug reactions precludes a patient from being re-challenged with that…
A: Stevens-Johnson syndrome is a severe and life threatening skin reaction that can be caused by some…
Q: explain why the protein binding of the drug is not correlated with the distribution or elimination…
A: Many drugs form drug macromolecule complexes by interacting with plasma, tissue proteins, or other…
Q: Drug X is available in two forms with the following aqueous solubilities: slightly solutble WA or a…
A: Oil based solutions are effective against most of the bacteria especially Salmonella enterica and…
Q: What is the minimal resolution required for gleaning insights into structures of drug-drug target…
A: The minimal resolution required for gleaning insights into the structures of drug-drug target…
Q: 60. You have 2 drugs A and B, drug A has a toxic dose of 100uq/kg and Minimal inhibitory…
A: Given data is: Drug AEffective Dose = EDA = 20 μg/kgToxic Dose = TDA = 100 μg/kg Drug BEffective…
Q: What are the Respective Structure Activity Relationship(SAR) of Sedative-hypnotic drugs? Please…
A: Sedative hypnotic drug-
Q: The clinical effectiveness of a drug majorly depends on: a. Clearance b. Potency c. Affinity to…
A: A drug is a natural or synthetic chemical substance that has a physiological effect when introduced…
Q: The EC50 and ED50 of a drug could be useful in determining which of the following parameter(s)?…
A: EC50 (Effective Concentration 50%): Effective Concentration 50%, or EC50, represents the…
Q: How much active ingredient in 20 cc of a 15% solution?
A: DISCLAIMER: Since you have asked multiple questions, we have solved the first question for you. If…
Q: Select all of the following which are true. A. Drug C has the smallest unsafe dose B. Drug C is the…
A: Drug response curve: A drug response curve expresses the relevance between a drug's action and the…
Q: How was thermal stability measured in this paper and describe how GRL-1720 and 5h affect the thermal…
A: Introduction- The Given article is about the novel coronavirus disease 2019 (COVID-19) which was…
Q: 32. The dose-response curves shown below represent responses of the metabotropic glutamate receptor…
A: The dose-response curve is the graphical representation that determines the relationship between the…
Q: Drug X has a toxic dose of 100mg/kg and a therapeutic dose of 10mg/kg. Drug Y also has a toxic dose…
A: Chemotherapeutic index. It is defined as the quantitative value of the relative safety of the drug.…
Q: Which of the following statements concerning drug delivery system is INCORRECT?* A.Drugs with good…
A: Introduction The term "drug" can refer to any substance that alters the functioning of the body…
Step by step
Solved in 4 steps
- Match the following drug targets with the type of antibiotic that uses them (answers may be used more than once or not at all). a. Cell wall b.Cell membrane c. Protein synthesis (Transcription/Translation) d. Metabolic Pathway e. Nucleic Acid synthesis Chloramphenicol Clindamycin Erythromycin Doxycycline Sulfonamides Answer these multiple-choice questions as well. Please give just the answer and no explanation. 1. Which is not true of virus capsids?a. They surround and protect viral nucleic acidb. Always icosahedral in shapec. Remain outside of host bacterial cells while the nucleic acid is injected into the bacterial celld. Enters host animal cells together with the nucleic acid e. Made up of protein subunits called capsomeres 2. All viruses have: a. DNA b. RNAc. Envelopesd. Glycoprotein spikes e. Host specificity 3. Use the following to select the sequence of events during replication of DNA viruses in animal cells:1 = replication of viral nucleic acid2 = adsorption3…Explain the uses of the minimum inhibitory concentration and thetherapeutic index in drug selection.Identify the binding interactions that might be possible for the drug reported below. Rank these interactions by increasing energy.
- Which agents associated with cumulative doses resulting in delayed myelotoxicity A Carmustine B Oxaliplatin C fosfamide D Methotrexate NEED DETAILED AND STEP BY STEP ANSWER WITH CORRECT OPTIONPlease explain this question and make me understand why D is the answer.You are administering tramadol to your patient. The order is for 600 mg. There are (3) concentrations available: a 300 mg/tab; a 200 mg/tab and a 100 mg/tab. Which concentration would be your best choice? How many tablets will you give? Group of answer choices a. 100 mg/tab; give 6 tablets b. 300 mg/tab; give 2 tablets c. 100 mg/tab; give 1 tablet d. 300 mg/tab; give 1/2 tablet e. 200 mg/tab; give 3 tablets f. 200 mg/tab; give 1/3 tablet
- What is the mechanism of action of the drug LIDOCAINE? pls. dont plagiarizeA patient is receiving morphine sulfate intravenously via a patient controlled analgesia (PCA) pump. The concentration of the solution is 11 mg/mL and is being infused continuously around the clock at a rate of 0.1 mL/hr. The patient may also access a 2-mg bolus dose every hour for breakthrough pain if needed and they are currently using an average of 5 additional bolus doses per day. The patient is to be converted to fentanyl using the table below. But before using the table we must determine their morphine usage, so what is this patient's total daily dosage of IV morphine? TABLE 10.3 FENTANYL TRANSDERMAL DOSAGE CONVERSION GUIDELINES", b Current Analgesic Oral morphine IM/IV morphine Oral oxycodone Oral codeine Oral hydromorphone IV hydromorphone IM meperidine Oral methadone 60-134 10-22 30-67 150-447 8-17 1.5-3.4 75-165 20-44 Recommended fentanyl transdermal system dose Fentanyl transdermal system 25 mcg/h Daily Dosage (mg/day) 135-224 23-37 67.5-112 17.1-28 3.5-5.6 166-278 45-74…Describe the Mechanisms of Drug Resistance with an example.
- Please help Can wearing a mask, limiting public spaces capacity, and having travel restrictions be justified because of Covid-19? Just a question not a writing assignment.Please choose all the ADVANTAGES of protein-based drugs such as antibodies compare to small molecules from the following options. A. high selectivity B. Biocompatibility C. stable to metabolism D. oral bioavailability E. long half-life F. high activityDescribe the mechanism of action of an ACE inhibitor. Based on this mechanism, when would ACE inhibitors be contraindicated