Answered: What is the minimal resolution required…

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

See similar textbooks

Related questions

Concept explainers

Question

What is the minimal resolution required for gleaning insights into structures of drug-drug target complex?

100A
2.5A
5A
10A
0.5A

Expert Solution

Step 1: Basic introduction of minimal resolution :

The minimal resolution required for gleaning insights into the structures of drug-drug target complexes typically depends on the specific target and the nature of the interactions involved. However, in general, a resolution of 2.5 angstroms (2.5Å) or better is considered a good starting point for studying protein-ligand interactions in drug discovery and structural biology. This level of resolution allows for the identification of key interactions, such as hydrogen bonds and hydrophobic interactions, which are important for understanding the binding mode and affinity of a drug to its target.

Step by step

Solved in 3 steps

SEE SOLUTION Check out a sample Q&A here

Knowledge Booster

Learn more about

Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.

Similar questions