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Which of the following adverse drug reactions precludes a patient from being re-challenged with that drug in the future?

a. Clostridium difficile superinfection from Moxifloxacin

b. All of them

c Stevens-Johnson syndrome from sulfamethoxazole +Trimethoprim

d. Itching/rash from Penicillin

e. Gastrointestinal upset from Clarithromycin

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