GWA studies reveal statistical correlations between thegenotypes at marker loci in genes and complex traits. DoGWA studies prove that allelic variation in a gene actually causes the variation in the trait? If not, what experiments could prove that allelic variants in a gene in apopulation are responsible for variation in a trait?
Genetic Variation
Genetic variation refers to the variation in the genome sequences between individual organisms of a species. Individual differences or population differences can both be referred to as genetic variations. It is primarily caused by mutation, but other factors such as genetic drift and sexual reproduction also play a major role.
Quantitative Genetics
Quantitative genetics is the part of genetics that deals with the continuous trait, where the expression of various genes influences the phenotypes. Thus genes are expressed together to produce a trait with continuous variability. This is unlike the classical traits or qualitative traits, where each trait is controlled by the expression of a single or very few genes to produce a discontinuous variation.
GWA studies reveal statistical correlations between the
genotypes at marker loci in genes and complex traits. Do
GWA studies prove that allelic variation in a gene actually causes the variation in the trait? If not, what experiments could prove that allelic variants in a gene in a
population are responsible for variation in a trait?
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