Which of the following best explains how individuals who inherit phenylketonuria alleles can avoid the symptoms of this disease (mental impairment, foul smelling urine)?
Which of the following best explains how individuals who inherit phenylketonuria alleles can avoid the symptoms of this disease (mental impairment, foul smelling urine)?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
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Which of the following best explains how individuals who inherit phenylketonuria alleles can avoid the symptoms of this disease (mental impairment, foul smelling urine)?

Transcribed Image Text:Which of the following best explains how individuals who inherit phenylketonuria alleles can avoid the symptoms of this disease (mental impairment, foul
smelling urine)?
It exhibits variable expressivity.
The expression of this disease depends on the environment. If the individual removes phenylalanine from their diet they can avoid the disease entirely.
PKU alleles are epistatic to alleles of another gene, which acts downstream in phenylalanine metabolism.
These individuals supplement their diets with enzymes that break-down phenylalanine.
O O O O
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Step 1
Phenylketonuria is an inherited disorder that increases the level of phenylalanine in the blood of such patients. In such patients the level of enzyme phenylalanine hydroxylase is reduced as a result phenylalanine is accumulated. This happens so because phenylalanine hydroxylase gene is mutated.
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