Genetic Inheritance Patterns: Retinitis pigmentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Usher’s Syndrome is an autosomal recessive inheritance (i.e., you must get a copy of the defective gene from your Mom and one from your Dad). Autosomal means it is not carried on one of the chromosomes that determines sex. One website (http://www.emedicine.com/oph/topic704.htm) says that Usher’s Syndrome Type II has been mapped to chromosome arm 1qe. Usher’s Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition 1) Draw a pedigree of Eric's family showing possible genotypes and chances of having RP. Within this pedigree, include Eric's parents, Eric himself, Eric's brother Dirk, and a daughter of Eric's. Be sure to follow all standard pedigree conventions. 2) Imagine you are a genetics counselor. Based upon the pattern of inheritance, what advice would you give Eric's brother Dirk about the chances of Dirk's children having RP? (Hint: Assume that there is a 1:80 chance that Dirk's wife is a carrier.) 3) How would your advice as a genetics counselor change if Dirk's wife has the disease? 4) Should Eric have children? Imagine he has a daughter (he has two, but both are adopted). What advice would you give a genetic daughter from your professional viewpoint?
Genetic Inheritance Patterns: Retinitis pigmentosa (RP) can be autosomal recessive, autosomal dominant, or x-linked. Apparently the dominant forms are often less severe. Usher’s Syndrome is an autosomal recessive inheritance (i.e., you must get a copy of the defective gene from your Mom and one from your Dad). Autosomal means it is not carried on one of the chromosomes that determines sex. One website (http://www.emedicine.com/oph/topic704.htm) says that Usher’s Syndrome Type II has been mapped to chromosome arm 1qe. Usher’s Type II is recessive, so for Eric this means that both his Mom and Dad are carriers of this condition
1) Draw a pedigree of Eric's family showing possible genotypes and chances of having RP. Within this pedigree, include Eric's parents, Eric himself, Eric's brother Dirk, and a daughter of Eric's. Be sure to follow all standard pedigree conventions.
2) Imagine you are a genetics counselor. Based upon the pattern of inheritance, what advice would you give Eric's brother Dirk about the chances of Dirk's children having RP? (Hint: Assume that there is a 1:80 chance that Dirk's wife is a carrier.)
3) How would your advice as a genetics counselor change if Dirk's wife has the disease?
4) Should Eric have children? Imagine he has a daughter (he has two, but both are adopted). What advice would you give a genetic daughter from your professional viewpoint?
Please answer in full as soon as possible. it is due this evening
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