Fucose, one of several monosaccharides found in the surface polysaccharides of animal cell membranes, is synthesized biochemically from mannose in the following eight steps. СНО -H- CH,OH CH,OH H,C H Но- H. Но- -H- ОН НО, CH3 ОН НО ОН НО НО ОН НО You H H HO- ČH,OH Mannose СНО H H H Но H- H CH, Но H НО OH CH3 Но VÓH HO H НО H- HO- НО НО H Но- H ČH3 Fucose
Catalysis and Enzymatic Reactions
Catalysis is the kind of chemical reaction in which the rate (speed) of a reaction is enhanced by the catalyst which is not consumed during the process of reaction and afterward it is removed when the catalyst is not used to make up the impurity in the product. The enzymatic reaction is the reaction that is catalyzed via enzymes.
Lock And Key Model
The lock-and-key model is used to describe the catalytic enzyme activity, based on the interaction between enzyme and substrate. This model considers the lock as an enzyme and the key as a substrate to explain this model. The concept of how a unique distinct key only can have the access to open a particular lock resembles how the specific substrate can only fit into the particular active site of the enzyme. This is significant in understanding the intermolecular interaction between proteins and plays a vital role in drug interaction.
How many stereoisomers would result from the reaction of fucose with methanol and acid catalysis?
1. Because there are four chiral centers, one would get 24 isomers.
2. One would get two isomers: the a- and b-anomers.
3. Two diastereomers would form by scrambling the stereochemistry of the carbon with a-hydrogens.
4. There would be no reaction and hence no stereoisomers would be created
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