10. Predict the product(s) of the following reaction, indicating stereochemistry where necessary: 1-chloro-1,4-diethylcyclohexane (the cthyl groups are trans to each other) reacting with WATER in methanol (solvent).
Reactions of Ethers
Ethers (R-O-R’) are compounds formed by replacing hydrogen atoms of an alcohol (R-OH compound) or a phenol (C6H5OH) by an aryl/ acyl group (functional group after removing single hydrogen from an aromatic ring). In this section, reaction, preparation and behavior of ethers are discussed in the context of organic chemistry.
Epoxides
Epoxides are a special class of cyclic ethers which are an important functional group in organic chemistry and generate reactive centers due to their unusual high reactivity. Due to their high reactivity, epoxides are considered to be toxic and mutagenic.
Williamson Ether Synthesis
An organic reaction in which an organohalide and a deprotonated alcohol forms ether is known as Williamson ether synthesis. Alexander Williamson developed the Williamson ether synthesis in 1850. The formation of ether in this synthesis is an SN2 reaction.
#10
![**Educational Content: Organic Chemistry Reactions**
**10. Reaction Prediction**
- Predict the product(s) of the following reaction, indicating stereochemistry where necessary:
- **Reactant**: 1-chloro-1,4-diethylcyclohexane (the ethyl groups are trans to each other).
- **Reactants/Conditions**: Water in methanol (solvent).
**11. Major Product Prediction**
- Predict the major products of each reaction. Identify the chiral products, if any.
a. **cis-4-ethylcyclohexanol** (as tosylate for ease of leaving) reacting with \(-CN\).
b. \((R)\) **2-chloro-2,3-dimethylhexane** with ethoxide anion in ethanol.
c. **1-bromo-2,3-dimethylcyclohexane** (methyl groups cis to each other, dash/dash) in ethanol (solvent).
**12. Synthesis Using Substitution**
- Synthesize the following using appropriate (\(S_N1\) or \(S_N2\)) substitution at some point in the synthetic route:
a. **1-aminobutane**
b. **t-butyl methyl ether** (a very dangerous compound)
c. **(CH₃)₂CCHCN**](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F9fa61ada-56b3-43bb-a096-aa43147ab223%2F5fd65bab-1930-4e21-83c7-119358b193b7%2Fhjb4krb_processed.jpeg&w=3840&q=75)
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