It is well reported that the antiallergic activity of Claritin (loratadine) is not only the result of the drug's action but it is also because of the action of two active metabolites. Draw the chemical structures of the corresponding metabolites and describe the type of the biochemical transformations involved. CH3 Loratadine (Claritin)

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Reactions at the Alpha Carbon Atom

The position next to the ketone or aldehyde functional group is termed as alpha position and the reaction which occurs at alpha position is called alpha substitution reaction. In an alpha substitution reaction, the alpha proton atom is substituted by an electrophile by the formation of an enol intermediate or enolate ion intermediate. Most of the carbonyl compounds go through an alpha substitution reaction.