Fragile X syndrome, caused by a change in the FMR1 gene, is the most common form of intellectual disability. In patients with this syndrome, a small part of the gene is repeated several times in one area of the chromosome. This defect in the gene makes the body unable to produce adequate amounts of a protein needed for normal brain functioning. In males, this syndrome causes a moderate intellectual disability, and in females, a mild intellectual disability. A family that exhibits Fragile X syndrome is shown in the pedigree. In the pedigree, squares represent males and circles represent females. Shaded symbols represent a person with the disorder. Which of the following correctly predicts the outcome if offspring 11 mated with a homozygous normal female, based on the inheritance pattern shown in the pedigree? A - The male offspring would exhibit Fragile X syndrome because Fragile X is an X-linked recessive trait. B - The female offspring would exhibit Fragile X syndrome because Fragile X is a recessive autosomal trait. C - None of their offspring would exhibit Fragile X syndrome because Fragile X is an X-linked dominant trait. D - Both the male and female offspring exhibit Fragile X syndrome because Fragile X is a dominant autosomal trait.
Fragile X syndrome, caused by a change in the FMR1 gene, is the most common form of intellectual disability. In patients with this syndrome, a small part of the gene is repeated several times in one area of the chromosome. This defect in the gene makes the body unable to produce adequate amounts of a protein needed for normal brain functioning. In males, this syndrome causes a moderate intellectual disability, and in females, a mild intellectual disability.
A family that exhibits Fragile X syndrome is shown in the pedigree. In the pedigree, squares represent males and circles represent females. Shaded symbols represent a person with the disorder.
Which of the following correctly predicts the outcome if offspring 11 mated with a homozygous normal female, based on the inheritance pattern shown in the pedigree?
A - The male offspring would exhibit Fragile X syndrome because Fragile X is an X-linked recessive trait.
B - The female offspring would exhibit Fragile X syndrome because Fragile X is a recessive autosomal trait.
C - None of their offspring would exhibit Fragile X syndrome because Fragile X is an X-linked dominant trait.
D - Both the male and female offspring exhibit Fragile X syndrome because Fragile X is a dominant autosomal trait.
Trending now
This is a popular solution!
Step by step
Solved in 2 steps
