Following is a Dixon plot for PNPP inhibition by inorganic phosphates. What answer choice shows the correct combination of the mode of inhibition and Ki of the El complex? [S] = 0.2 mM "[S] = 0.4 mM I/Vav 8 7 y=0.01357x+3.6976 6 10 5 4 3 2 1 y=0.0795x+2.7693 -30 -20 -10 0 10 20 30 [I](M) Mixed inhibition, Ki= -21.2 UM Mixed inhibition, Ki= 1/16.5 uM Competitive inhibition, Ki= 16.5 UM

Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
icon
Related questions
Question

Following is a Dixon plot for PNPP inhibition by inorganic phosphates. What answer choice shows the correct combination of the mode of inhibition and Ki of the EI complex?

Following is a Dixon plot for PNPP inhibition
by inorganic phosphates. What answer choice
shows the correct combination of the mode of
inhibition and Ki of the El complex?
[S] = 0.2 mM
"[S] = 0.4 mM
I/Vav
8
7
y=0.01357x+3.6976
6
10
5
4
3
2
1
y=0.0795x+2.7693
-30
-20
-10
0
10
20
30
[I](M)
Mixed inhibition, Ki= -21.2 UM
Mixed inhibition, Ki= 1/16.5 uM
Competitive inhibition, Ki= 16.5 UM
Transcribed Image Text:Following is a Dixon plot for PNPP inhibition by inorganic phosphates. What answer choice shows the correct combination of the mode of inhibition and Ki of the El complex? [S] = 0.2 mM "[S] = 0.4 mM I/Vav 8 7 y=0.01357x+3.6976 6 10 5 4 3 2 1 y=0.0795x+2.7693 -30 -20 -10 0 10 20 30 [I](M) Mixed inhibition, Ki= -21.2 UM Mixed inhibition, Ki= 1/16.5 uM Competitive inhibition, Ki= 16.5 UM
Expert Solution
trending now

Trending now

This is a popular solution!

steps

Step by step

Solved in 2 steps

Blurred answer
Similar questions
  • SEE MORE QUESTIONS
Recommended textbooks for you
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781319114671
Author:
Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:
W. H. Freeman
Lehninger Principles of Biochemistry
Lehninger Principles of Biochemistry
Biochemistry
ISBN:
9781464126116
Author:
David L. Nelson, Michael M. Cox
Publisher:
W. H. Freeman
Fundamentals of Biochemistry: Life at the Molecul…
Fundamentals of Biochemistry: Life at the Molecul…
Biochemistry
ISBN:
9781118918401
Author:
Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:
WILEY
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305961135
Author:
Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:
Cengage Learning
Biochemistry
Biochemistry
Biochemistry
ISBN:
9781305577206
Author:
Reginald H. Garrett, Charles M. Grisham
Publisher:
Cengage Learning
Fundamentals of General, Organic, and Biological …
Fundamentals of General, Organic, and Biological …
Biochemistry
ISBN:
9780134015187
Author:
John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:
PEARSON