Below is a plot of Vo vs. [S] for a specific allosteric enzyme under different conditions. Which ofthe following best describes the graph?4(S]O Adding a positive modulator to #2 would result in curve 3.Curve 1 represents maximum inhibition.Line 4 is valid exclusively for curves 1 and 2.Adding a positive modulator to #1 would result in curve 2.O Curve 3 represents the effect of a negative modulator added to curve 2.

Allosteric enzymes have more than one active site and change their conformational ensemble upon…

Answered: O Curve 3 represents the effect of a…

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Anatomy and Physiology

O Curve 3 represents the effect of a negative modulator added to curve 2.

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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13) Draw a graph representing the changes in membrane potential across the axonal membrane before, during, and after an action potential. On your graph, use a highlighter to clearly indicate for which portions of your graph the letter corresponding to each cellular event listed below belongs. List of cellular events: A) All K* channels open B) All Na* channels close C) The Na*/K* ATPase cotransporter transports Na* and K* across the membrane. D) All Na* channels open E) The threshold value of membrane potential is attained. F) All K* channels close G) Some Na* channels open Your graph:
A A Aa v Ao O... 11 AaBbCcDdEe AaBbCcDc AaBbCcDdE AaBb( AaBbCcDdEE AaBbCcDdEe U v ab A ev A v X, Normal No Spacing Heading 1 Heading 2 Title Subtitle temporal summation spatial summation Unidirectional and non-degrading Action potential o Depolarization; Na gates opening o Repolarization: K gates opening o Hyperpolarization: K gates closing Movement down an axon Refractory periods Myelin and Axon size effect Action potential stimulated release Neurotransmitter (NT) recycling Neurotransmitters o Acetylcholine Biological amines (Serotonin, norepinephrine and epinephrine) Single amino acids (Glutamate and GABA) Fast and Slow effects and Receptor effects The Autonomic System Division definition
A Na+ 10 msec B 40mV Ca²+ C Na+ Ca²+ Each graph represents the depolarization activity during an action potential in Xenopus spinal cells at different stages of development. Referring to each electrical reading (A, B, and C), place the graphs in order of developmental stage, from earliest to latest. What are the major changes in action potential activity that occurs with development?
Place the following events in chronological order from 1-8: Nat enters the cell, and depolarization occurs to approximately +30 mV. The voltage across the cell membrane is -70 mV, the resting membrane potential. Upon reaching the peak of the action potential, the VG Nat channels are inactivated by the closing of their inactivation gate and the activation gate of each VG K channel opens. VG K channels close by the closing of their activation gate, and the resting membrane potential is gradually restored. An excitatory post-synaptic potential depolarizes the membrane to threshold and the activation gate of VG Nat channels open. Upon returning to the resting membrane potential, VG Na channels are reset by opening of the inactivation gate and the closing of the activation gate. VG K+ channels are slow to close, resulting in an excess of K* efflux and hyperpolarization. Depolarization occurs as K+ flows out of the cell.
Is this circuit correct?
33 Explain how the transmission of an action potential would be impacted if voltage-gated calcium channels could not open. In your answer, explain the usual process ofhow an action potential is transmitted from one neuron to the next neuron.Answer in a sentence format.
1.25 p Question 22 Which statement below best describes why action potentials travel in only one direction? O The all-or-none principle explains this. O They have a refractory period. O The diameter of the axon explains this. O Only sodium- and potassium-gated channels are found on the axon. O They have myelinated axons. • Previous Next Not saved Submi
threshold resting membrane potential decrease calcium channels increase action potentials The autonomic nervous system influences the heart rate. A sympathetic signal (norepinephrine) results in opening. This accelerates the process of reaching thereby resulting in a in time between successive action potentials. A parasympathetic signal (acetylcholine) results in the dropping to -70mV. This results in an in time for cells to reach threshold, thereby increasing the time between successive
-60mV -90mV -70mk Refer to the figure of 3 action potentials. The spike height of this/these action potential(s) would depend on the concentration of extracellular sodium. A and B A only B only C only B and C
11) Compare the propagation speeds of an action potential along an axon that is 10 µM in diameter and one that is 20 uM in diameter. You must have a quantitative answer. 12) How would the velocity of action potential propagation change if you quadrupled the membrane conductance? You must have a quantitative answer. 13) You discover a mutation in mice that causes them to suddenly lose their myelin sheaths. How would this mutation change the speed of action potential propagation and why? 9
For the ion concentrations in Table 12.1, calculate the equilibriumpotentials for each ion species in squid axons and in mammalianmuscle fibers.
1. What is action potential? Please describe the ionic mechanisms of depolarization and repolarization phase of action potential in the squid giant axon. please write more and more