Folic acid is synthesized in bacteria as dihydrofolate, in a pathway starting from guanosine triphosphate. In this pathway, C-8 is lost as formate. From the structural similarities between guanine and pterin, predict which carbon and nitrogen atoms of GTP are the precursors to N-1, C-2, C-4, N-5, C-7, N-8, and C-9 of dihydrofolate. 5 10 PABAGIU HN 4 7 H,N2 N 1 Dihydrofolate 7 HN 8. H,N 2 N4 3 PP.PO 5' 3 2 ÓH ÓH GTP ZI

Biochemistry
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ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
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Chapter1: Biochemistry: An Evolving Science
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Folic acid is synthesized in bacteria as dihydrofolate, in a pathway starting
from guanosine triphosphate. In this pathway, C-8 is lost as formate. From
the structural similarities between guanine and pterin, predict which carbon
and nitrogen atoms of GTP are the precursors to N-1, C-2, C-4, N-5, C-7,
N-8, and C-9 of dihydrofolate.
Transcribed Image Text:Folic acid is synthesized in bacteria as dihydrofolate, in a pathway starting from guanosine triphosphate. In this pathway, C-8 is lost as formate. From the structural similarities between guanine and pterin, predict which carbon and nitrogen atoms of GTP are the precursors to N-1, C-2, C-4, N-5, C-7, N-8, and C-9 of dihydrofolate.
5
10
PABAGIU
HN 4
7
H,N2 N
1
Dihydrofolate
7
HN
8.
H,N 2 N4
3
PP.PO
5'
3 2
ÓH ÓH
GTP
ZI
Transcribed Image Text:5 10 PABAGIU HN 4 7 H,N2 N 1 Dihydrofolate 7 HN 8. H,N 2 N4 3 PP.PO 5' 3 2 ÓH ÓH GTP ZI
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