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FIGURE 18-14 Nudeotide variation for 5102 bp of the G6PD gene for a woridwide sample of 47 men. Only the 18 variable sites are shown. The functional allele ddass (A,A", or B) is shown for each sequence. SNP2 is a nonsynonymous SNP that causes a valine-to- methionine change that underies differences in enzyme activity associated with the A allele. SNP3 is a nonsynonymous SNP that causes an aspartic-acid-to-asparagine amino acid change. [Data from M.A. Saunders at al, Ganetics 162, 2002, 1849-1861.| 18.4 Genetic Variation and Its Measurement 685 Nucleotide variation at the G6PD gene in humans Origin SNP Individual Allele 1 2 3 6 7 8 9 10 11 12 13 14 15 16 17 18 AGAC CG C C CcC G GCT CACH T T • T.T Southem African GAG G GAG G GAG. G. . T .T. GAG. G. . T .T. . GAG. G. T . T A- G 1 .. C . G. 1 . C. G 1 .. C G 1 .C. G 1 •C. G 2 . C G. 2 . C. G. 3 CTG. 4 •CT G . 4 .. CT G. 5 . CTG. 6 A.C G7 • TC. G. 8 TC. G. • TC. G 8 •TC. G. • TC. G. Central African Central African A- A- 4. Atrican American A- 5 Atrican American A- 6 Central African Central African A- GAG.G • T•I G.G.. . . .. T G.G . A+ Central African Central African A+ .T.. 10 Southerm African A . 11 Southern African 12 Southen African 13 Southerm African 14 Southen African 15 Central African 16 European European European Southwest Asian 17 18 19 20 East Asian •CG 3 C.G. 9 .. 10 .. 10 .. 10 . 10 . 10 • 10 . 10 • 10 . 10 . 10 . 10 21 22 23 Native American Southern African Native American 24 Native American 25 Native American 26 Native American 27 Native American 28 Native American 29 30 31 Native American Native American Native American 32 European European European European European European Southwest Asian 33 • 10 10 34 35 • 10 . 10 . 10 . 10 . 10 • 10 36 37 38 30 East Asian 40 East Asian 41 East Asian • 10 42 East Asian • 10 43 East Asian • 10 44 East Asian • 10 45 East Asian 10 46 Pacific Islander • 11 47 East Asian T 12 Haplotype

FIGURE 18-14 Nudeotide variation for 5102 bp of the G6PD gene for a woridwide sample of 47 men. Only the 18 variable sites are shown. The functional allele ddass (A,A", or B) is shown for each sequence. SNP2 is a nonsynonymous SNP that causes a valine-to- methionine change that underies differences in enzyme activity associated with the A allele. SNP3 is a nonsynonymous SNP that causes an aspartic-acid-to-asparagine amino acid change. [Data from M.A. Saunders at al, Ganetics 162, 2002, 1849-1861.| 18.4 Genetic Variation and Its Measurement 685 Nucleotide variation at the G6PD gene in humans Origin SNP Individual Allele 1 2 3 6 7 8 9 10 11 12 13 14 15 16 17 18 AGAC CG C C CcC G GCT CACH T T • T.T Southem African GAG G GAG G GAG. G. . T .T. GAG. G. . T .T. . GAG. G. T . T A- G 1 .. C . G. 1 . C. G 1 .. C G 1 .C. G 1 •C. G 2 . C G. 2 . C. G. 3 CTG. 4 •CT G . 4 .. CT G. 5 . CTG. 6 A.C G7 • TC. G. 8 TC. G. • TC. G 8 •TC. G. • TC. G. Central African Central African A- A- 4. Atrican American A- 5 Atrican American A- 6 Central African Central African A- GAG.G • T•I G.G.. . . .. T G.G . A+ Central African Central African A+ .T.. 10 Southerm African A . 11 Southern African 12 Southen African 13 Southerm African 14 Southen African 15 Central African 16 European European European Southwest Asian 17 18 19 20 East Asian •CG 3 C.G. 9 .. 10 .. 10 .. 10 . 10 . 10 • 10 . 10 • 10 . 10 . 10 . 10 21 22 23 Native American Southern African Native American 24 Native American 25 Native American 26 Native American 27 Native American 28 Native American 29 30 31 Native American Native American Native American 32 European European European European European European Southwest Asian 33 • 10 10 34 35 • 10 . 10 . 10 . 10 . 10 • 10 36 37 38 30 East Asian 40 East Asian 41 East Asian • 10 42 East Asian • 10 43 East Asian • 10 44 East Asian • 10 45 East Asian 10 46 Pacific Islander • 11 47 East Asian T 12 Haplotype

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Suppose that the seven chromosomes in Figure 18-4a
represent a random sample of chromosomes from a
population.
a. Calculate gene diversity (GD) separately for the
indel, the microsatellite locus, and the SNP at position 3.
b. If the sequence was shortened so that you had data
only for positions 1 through 24, how many haplotypes
would there be?
c. Calculate the linkage disequilibrium parameter (D)
between the SNPs at positions 29 and 33.

FIGURE 18-14 Nudeotide variation for 5102 bp of the G6PD gene for a woridwide sample of 47 men. Only the 18 variable sites are shown. The functional allele ddass (A,A", or B) is shown for each sequence. SNP2 is a nonsynonymous SNP that causes a valine-to- methionine change that underies differences in enzyme activity associated with the A allele. SNP3 is a nonsynonymous SNP that causes an aspartic-acid-to-asparagine amino acid change. [Data from M.A. Saunders at al, Ganetics 162, 2002, 1849-1861.| 18.4 Genetic Variation and Its Measurement 685 Nucleotide variation at the G6PD gene in humans Origin SNP Individual Allele 1 2 3 6 7 8 9 10 11 12 13 14 15 16 17 18 AGAC CG C C CcC G GCT CACH T T • T.T Southem African GAG G GAG G GAG. G. . T .T. GAG. G. . T .T. . GAG. G. T . T A- G 1 .. C . G. 1 . C. G 1 .. C G 1 .C. G 1 •C. G 2 . C G. 2 . C. G. 3 CTG. 4 •CT G . 4 .. CT G. 5 . CTG. 6 A.C G7 • TC. G. 8 TC. G. • TC. G 8 •TC. G. • TC. G. Central African Central African A- A- 4. Atrican American A- 5 Atrican American A- 6 Central African Central African A- GAG.G • T•I G.G.. . . .. T G.G . A+ Central African Central African A+ .T.. 10 Southerm African A . 11 Southern African 12 Southen African 13 Southerm African 14 Southen African 15 Central African 16 European European European Southwest Asian 17 18 19 20 East Asian •CG 3 C.G. 9 .. 10 .. 10 .. 10 . 10 . 10 • 10 . 10 • 10 . 10 . 10 . 10 21 22 23 Native American Southern African Native American 24 Native American 25 Native American 26 Native American 27 Native American 28 Native American 29 30 31 Native American Native American Native American 32 European European European European European European Southwest Asian 33 • 10 10 34 35 • 10 . 10 . 10 . 10 . 10 • 10 36 37 38 30 East Asian 40 East Asian 41 East Asian • 10 42 East Asian • 10 43 East Asian • 10 44 East Asian • 10 45 East Asian 10 46 Pacific Islander • 11 47 East Asian T 12 Haplotype
Transcribed Image Text:FIGURE 18-14 Nudeotide variation for 5102 bp of the G6PD gene for a woridwide sample of 47 men. Only the 18 variable sites are shown. The functional allele ddass (A,A", or B) is shown for each sequence. SNP2 is a nonsynonymous SNP that causes a valine-to- methionine change that underies differences in enzyme activity associated with the A allele. SNP3 is a nonsynonymous SNP that causes an aspartic-acid-to-asparagine amino acid change. [Data from M.A. Saunders at al, Ganetics 162, 2002, 1849-1861.| 18.4 Genetic Variation and Its Measurement 685 Nucleotide variation at the G6PD gene in humans Origin SNP Individual Allele 1 2 3 6 7 8 9 10 11 12 13 14 15 16 17 18 AGAC CG C C CcC G GCT CACH T T • T.T Southem African GAG G GAG G GAG. G. . T .T. GAG. G. . T .T. . GAG. G. T . T A- G 1 .. C . G. 1 . C. G 1 .. C G 1 .C. G 1 •C. G 2 . C G. 2 . C. G. 3 CTG. 4 •CT G . 4 .. CT G. 5 . CTG. 6 A.C G7 • TC. G. 8 TC. G. • TC. G 8 •TC. G. • TC. G. Central African Central African A- A- 4. Atrican American A- 5 Atrican American A- 6 Central African Central African A- GAG.G • T•I G.G.. . . .. T G.G . A+ Central African Central African A+ .T.. 10 Southerm African A . 11 Southern African 12 Southen African 13 Southerm African 14 Southen African 15 Central African 16 European European European Southwest Asian 17 18 19 20 East Asian •CG 3 C.G. 9 .. 10 .. 10 .. 10 . 10 . 10 • 10 . 10 • 10 . 10 . 10 . 10 21 22 23 Native American Southern African Native American 24 Native American 25 Native American 26 Native American 27 Native American 28 Native American 29 30 31 Native American Native American Native American 32 European European European European European European Southwest Asian 33 • 10 10 34 35 • 10 . 10 . 10 . 10 . 10 • 10 36 37 38 30 East Asian 40 East Asian 41 East Asian • 10 42 East Asian • 10 43 East Asian • 10 44 East Asian • 10 45 East Asian 10 46 Pacific Islander • 11 47 East Asian T 12 Haplotype
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