Exercise 3 on the following pages is referring to a disputed 2010 study claiming that bacteria isolated from Mono Lake ([As] = 200 μM, more than 1000x the legal limit in drinking water) can substitute As instead of P into its DNA. Skeptical of the textbook’s framing on this, you find the following data in which the free energy profiles for hydrolysis of As and P esters through two transition states are predicted by computational methods. Based on your knowledge of chemical kinetics and DNA structure, why do you think it is unlikely that organisms use As in place of P?

Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Exercise 3 on the following pages is referring to a disputed 2010 study claiming
that bacteria isolated from Mono Lake ([As] = 200 μM, more than 1000x the legal limit in
drinking water) can substitute As instead of P into its DNA.

Skeptical of the textbook’s framing on this, you find the following data in which the free
energy profiles for hydrolysis of As and P esters through two transition states are
predicted by computational methods. Based on your knowledge of chemical kinetics
and DNA structure, why do you think it is unlikely that organisms use As in place of P? 

 

TS1
TS1
E, kcalimol
но-
40
но
HO
35
35
30
kcal/mol
25
20
20
X- As, P
kcal/mol
15
10
5
"O-
X-O-R
HO-
НО—R
O-x=0
Transcribed Image Text:TS1 TS1 E, kcalimol но- 40 но HO 35 35 30 kcal/mol 25 20 20 X- As, P kcal/mol 15 10 5 "O- X-O-R HO- НО—R O-x=0
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