Enzyme-substrate complex Enzyme What concept does this picture illustrate? 4° structure hydrogen bonding Enzyme activity as a function of substrate concentration Enzyme catalysis by proximity and orientation Induced-fit model of substrate binding Lowering of activation energy barrier

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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**Enzyme-Substrate Interaction and Induced-Fit Model**

In the diagram:

1. **Left Side:**
   - It shows an enzyme with an active site labeled.
   - A substrate, depicted as a molecule with a complementary shape, is shown approaching the enzyme's active site.

2. **Right Side:**
   - It illustrates the enzyme-substrate complex formed after the substrate binds to the enzyme's active site.
   - The substrate conforms slightly to fit into the enzyme, demonstrating the induced-fit model.

**Question:**

**What concept does this picture illustrate?**

- 4° structure hydrogen bonding
- Enzyme activity as a function of substrate concentration
- Enzyme catalysis by proximity and orientation
- Induced-fit model of substrate binding
- Lowering of activation energy barrier

The correct concept illustrated by the picture is the "Induced-fit model of substrate binding". This model suggests that the active site of the enzyme molds itself around the substrate for a tighter fit upon binding, which is crucial for the enzyme's catalytic activity.
Transcribed Image Text:**Enzyme-Substrate Interaction and Induced-Fit Model** In the diagram: 1. **Left Side:** - It shows an enzyme with an active site labeled. - A substrate, depicted as a molecule with a complementary shape, is shown approaching the enzyme's active site. 2. **Right Side:** - It illustrates the enzyme-substrate complex formed after the substrate binds to the enzyme's active site. - The substrate conforms slightly to fit into the enzyme, demonstrating the induced-fit model. **Question:** **What concept does this picture illustrate?** - 4° structure hydrogen bonding - Enzyme activity as a function of substrate concentration - Enzyme catalysis by proximity and orientation - Induced-fit model of substrate binding - Lowering of activation energy barrier The correct concept illustrated by the picture is the "Induced-fit model of substrate binding". This model suggests that the active site of the enzyme molds itself around the substrate for a tighter fit upon binding, which is crucial for the enzyme's catalytic activity.
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