Which of the following principles are exploited by enzymes to reduce activation energy barrier of a reaction? (multiple correct answers possible) Exclude water from the active site of the enzyme Participate in the reaction, i.e., sidestep the transition state of the solution reaction O Bring the substrates of a reaction into close proximity and orientation to each other Provide an acidic or basic residue in the active site Bind tighter to the transition state than to the substrates or products of a reaction Their presencealone produce a crowding effect, i.e., produce an increase of the effective concentration of substrate

Which of the following principles are exploited by enzymes to reduce activation energy barrier of a reaction? (multiple correct answers possible) Exclude water from the active site of the enzyme Participate in the reaction, i.e., sidestep the transition state of the solution reaction O Bring the substrates of a reaction into close proximity and orientation to each other Provide an acidic or basic residue in the active site Bind tighter to the transition state than to the substrates or products of a reaction Their presencealone produce a crowding effect, i.e., produce an increase of the effective concentration of substrate

Biochemistry

9th Edition

ISBN:9781319114671

Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.

Chapter1: Biochemistry: An Evolving Science

Section: Chapter Questions

Problem 1P

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Question

Can you please help which answers if fitting for lowering the activation energy?

Which of the following principles are exploited by enzymes to reduce
activation energy barrier of a reaction? (multiple correct answers
possible)
Exclude water from the active site of the enzyme
O Participate in the reaction, i.e., sidestep the transition state of the solution
reaction
O Bring the substrates of a rcaction into close proximity and orientation to
each other
Provide an acidic or basic residue in the active site
Bind tighter to the transition state than to the substrates or products of a
reaction
Their presencealone produce a crowding effect, i.e. produce an increase of
the effective concentration of substrate

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