Elena is an 8-year-old girl with a history of asthma and allergy to bee stings. She has been brought to the clinic complaining of a throat infection. Her health care provider prescribes a course of penicillin to manage her current infection and cautions her parents to watch her closely for a reaction. 1. Explain the role of IgE and mast cells in type I hypersensitivity reactions at the cellular level. 2. With the release of histamine, what changes will occur at the cellular and tissue levels? 3. What manifestations will be exhibited as a result of the histamine release?

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