draw out the mechanism of the following reaction. be sure to draw all intermediates and use arrows to show the flow of electrons: GTP + IMP + L-Asp-> GDP + phosphate + N6-(1,2-dicarboxyethyl) - AMP
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- One of the later steps in glucose biosynthesis is the isomerization of fructose 6-phosphate to glucose 6-phosphate. Propose a mechanism, using acid or base catalysis as needed.Which of the following bases are strong enough to deprotonate CH3CH2CH2C≡CH (pKa = 25) so that equilibrium favors the products: (a) H2O; (b) NaOH; (c) NaNH2; (d) NH3; (e) NaH; (f) CH3Li?PQ-22. Which structure is a reasonable intermediate in the acid-catalyzed hydrolysis of ethyl acetate, shown, in dilute aqueous acid? O O (A) H3C-C-OCH₂CH3 OH OH₂ (C) H3C-C-OCH₂CH3 H OH (B) H3C-C-OCH₂CH3 OH2 O (D) H3C-C
- Lysine catabolism begins with reductive amination of a-ketoglutarate to give saccharopine in a multistep process. Draw curved arrows to show the movement of electrons in this step of the reaction mechanism. Arrow-pushing Instructions 7 COO H NH3 COO OOC B: COO H NH3 COO BH+Look at the reaction given, the product is 9,10-anthraquinone. Please draw a mechanism for another possible structure from the reaction, emodin. -OH IL,SO, A CIf a chemist attempted to carry out the coupling of the two a-ketoacids shown in the mechanism WITHOUT using the enzyme, what product (or products) would you expect? (I'm providing the whole mechanism here again to help you consider this question.) OH CH;- CH OH 00 CH CH;CH, R 10 B: H, ОН CH, CH, ČH,CH, R- HO `CH,CH3 CH CH,CH, CH CH;CH, HO HO `CH,CH3 НО `CH3 HO `CH3 CH,CH; A C D O only D all of these would be possible O only A O only B only C
- Predict the organic product for the reaction. OH K₂Cr₂O7 H₂SO4 :ÖH acetone Select Draw Templates More H₂CrO4 |||||||CH 0 Add four curved arrows to complete the intermolecular mechanism that forms the oxidized product. Note that potassium dichromate in acid is in equilibrium with chromic acid used. 3 Select Draw Templates More H H 0: C H H Cr 0 : OH Q : 0:Which of the following bases are strong enough to deprotonate C6H5OH (pKa = 10) so that equilibrium favors the products: (a) H2O; (b) NaOH; (c) NaNH2; (d) CH3NH2; (e) NaHCO3; (f) NaSH; (g) NaH?Please write the full mechanism of the following reaction
- CF 3- Celecoxib -SO2NH2 Do the following synthesis reactions. ŞO₂NH₂ NHNH2 A +I got to making an epoxide and organometal complex but then got confused as to what happens next with the H3O+ workup.4. Pyridoxal Phosphate Reaction Mechanisma Threonine can be broken down by the enzyme threonine dehydratase, which catalyzes the conversion of threonine to alpha:ketobutzrate, and ammonia. The enzyme uses PLP as a cofactor. Suggest a mechanism for this reaction, based on the mechanisms in Figure 18-6. Note that this reaction includes an elimination at the betta carbon of threonine. OH NH, PLP threonine dehydratase CH-CH-CHCOO- CH-CH-C-COO + NH, + H,0 Threonine a-Ketobutyrate

