Discuss how diabetic ketoacidosis (DKA) occurs and its clinical manifestations. In your response be sure to address the following points (i) the three events that characterize DKA; (ii) the underlying molecular causes of each of the three events; (iii) the clinical manifestations and treatments of DKA.
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- Assume you have a monoclonal antibody specific for phosphotyrosine. How do you anticipate the antibody affecting insulin signalling?Arachidonic (AA) acid is an important lipidinvolved in the production of inflammatorymediators such as prostaglandins. A commontreatment of inflammatory conditions is theadministration of corticosteroids. These drugslower the expression of sPLA2. Describe howcorticosteroid use leads to the lowering ofprostaglandins.The one i have to use to answer these questions are Prolactin please :)
- Possible treatments, if any, along with their biochemical basis of inherited metabolic disease of Congential Adrenal Hyperplasia . Show the chemical structures of any drugs that are discussed as well as their mechanism of action.For each of the following examples, indicate whether the drug is acting on physical process, chemical process or enzymatic system (your answer should be only; Physical, Chemical or Enzymatic). A. A drug is used as an antidote in lead poisoning and acts by binding to lead particles in body (chelation therapy). B. A drug acts to reduce flatulence and acts by reducing the surface tension of intestinal gas bubbles in the GI tract (e.g. Simethicone). C. A drug competes with alpha-glucosidase in intestine to reduce glucose conversion from disaccharides (e.g. Acarbose).Because of prolonged stress created by the COVID 19 pandemic, many people have experienced adrenal fatigue created by the General Adaptation Syndrome. Please explain, using COVID-19 as an example, what this is and how this process develops into adrenal fatigue or organ collapse. Be sure to explain each stage of GAS and which/how hormones are involved in your answer.
- What is the mechanism(s) of action of the drug Riluzole in MND?Hemophilia B, an X-linked genetic disorder which highly affects males, is a condition in which levels of Factor VIII are significantly decreased. Please describe the physiologic pathway which utilizes Factor VIII and describe the consequences of missing this factor from a physiologic perspective.Name two proteins that are effectors of the insulin signaling pathway in adipocytes, liver, or muscle cells. Explain how these effector proteins address the conditions that triggered insulin release.
- Name 2 FDA approved drugs for the treatment of diabetic neuropathy and for each state its mechanism of action. Cite your source of information.Answer the following step by step A) How many milliliters of 1:100 epinephrine are needed for a 5 mg dose? B) How many milligrams are there in a 1cc dose of 2% Xylocaine? C)You have 20% acetylcysteine; how many milliliters do you need of this to form 4 ml of 8% solution?Provide annotated structure image/diagram of the EPH RECEPTOR B2 (EPHB2). Giving the ligand bidning sites.