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define these terms Clearance (CL) Bioavailability (F) Distribution volume (Vd) Area under the curve (AUC) Half-life (t1 / 2

define these terms Clearance (CL) Bioavailability (F) Distribution volume (Vd) Area under the curve (AUC) Half-life (t1 / 2

Phlebotomy Essentials
Phlebotomy Essentials
6th Edition
ISBN:9781451194524
Author:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Publisher:Ruth McCall, Cathee M. Tankersley MT(ASCP)
Chapter1: Phlebotomy: Past And Present And The Healthcare Setting
Section: Chapter Questions
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define these terms Clearance (CL) Bioavailability (F) Distribution volume (Vd) Area under the curve (AUC) Half-life (t1 / 2)

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Step 1

Drug

Medication or medicine that alters physiological changes when consumed. 

Factors affecting drug absorption are,

  • Physicochemical properties
  • Drug formulation (e.g., tablets, capsules, solutions)

Physiochemical properties, include many factors such as,

  • Solubility, partition Coefficient and dissociation constant
  • Hydrogen Bonding and ionization of Drug
  • Redox Potential, complexation
  • Surface activity and protein binding.
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