Hb % Saturation pH 7.4 pH 7.2 KI Tissue 80 20 Hb Saturation Curve 0 Lungs 0 10 20 30 40 50 50 70 80 90 100 110 120 130 Partal Pressure (oxygen) a. Partial pressure is a way to measure the concentration of oxygen. The two arrows show the concentration of oxygen in the tissues and in the lungs. Why do you think the percent oxygen is high in the lungs and low in the tissues (1 sentence)? b. Hb % saturation is the percent of hemoglobin molecules that have bound oxygen. At 100% saturation, all of the oxygen-binding sites of hemoglobin are bound. The graphs shows two lines depicting how saturated hemoglobin would be at the different oxygen concentrations in an environment of pH7.2 (lower line) and 7.4 (upper line). Is hemoglobin in the tissues (i.e. 40 pp oxygen) more likely to be saturated at 7.2 or 7.4 (circle one)? c. In 1-2 sentences, summarize what the two lines in the graph tell you about hemoglobin's response to changes in pH. 5. Delivering oxygen to your tissues is a pretty important iob. Since pH afects that ioh it is easy

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Hb % Saturation
100
80
60
20
0
pH 7.4
pH 7.2
A
Tissue
Hb Saturation Curve
0 10 20 30
40
Lungs
50 60 70 80 90 100 110
Partal Pressure (oxygen)
120 130
a. Partial pressure is a way to measure the concentration of oxygen. The two arrows
show the concentration of oxygen in the tissues and in the lungs. Why do you think the percent
oxygen is high in the lungs and low in the tissues (1 sentence)?
b. Hb % saturation is the percent of hemoglobin molecules that have bound oxygen. At
100% saturation, all of the oxygen-binding sites of hemoglobin are bound. The graphs shows
two lines depicting how saturated hemoglobin would be at the different oxygen concentrations in
an environment of pH7.2 (lower line) and 7.4 (upper line).
Is hemoglobin in the tissues (i.e. 40 pp oxygen) more likely to be saturated at 7.2 or 7.4 (circle
one)?
c. In 1-2 sentences, summarize what the two lines in the graph tell you about
hemoglobin's response to changes in pH.
5. Delivering oxygen to your tissues is a pretty important job. Since pH afects that job, it is easy
to understand why our body has to maintain a fairly constant pH. This is done with molecules
that can bind up excess protons (hydrogen ions) or hydroxide ions. Such molecules make up
what we call a buffer. An acid-base buffer typically consists of a weak acid, and its conjugate
base (salt). Definition of an acid="it donates protons"; definition of a base="it accepts protons".
Buffers work because the concentrations of the weak acid and its salt are large compared to the
amount of protons or hydroxide ions added or removed. Our blood buffer system is called the
carbonic acid buffer system:
Transcribed Image Text:Hb % Saturation 100 80 60 20 0 pH 7.4 pH 7.2 A Tissue Hb Saturation Curve 0 10 20 30 40 Lungs 50 60 70 80 90 100 110 Partal Pressure (oxygen) 120 130 a. Partial pressure is a way to measure the concentration of oxygen. The two arrows show the concentration of oxygen in the tissues and in the lungs. Why do you think the percent oxygen is high in the lungs and low in the tissues (1 sentence)? b. Hb % saturation is the percent of hemoglobin molecules that have bound oxygen. At 100% saturation, all of the oxygen-binding sites of hemoglobin are bound. The graphs shows two lines depicting how saturated hemoglobin would be at the different oxygen concentrations in an environment of pH7.2 (lower line) and 7.4 (upper line). Is hemoglobin in the tissues (i.e. 40 pp oxygen) more likely to be saturated at 7.2 or 7.4 (circle one)? c. In 1-2 sentences, summarize what the two lines in the graph tell you about hemoglobin's response to changes in pH. 5. Delivering oxygen to your tissues is a pretty important job. Since pH afects that job, it is easy to understand why our body has to maintain a fairly constant pH. This is done with molecules that can bind up excess protons (hydrogen ions) or hydroxide ions. Such molecules make up what we call a buffer. An acid-base buffer typically consists of a weak acid, and its conjugate base (salt). Definition of an acid="it donates protons"; definition of a base="it accepts protons". Buffers work because the concentrations of the weak acid and its salt are large compared to the amount of protons or hydroxide ions added or removed. Our blood buffer system is called the carbonic acid buffer system:
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