cycle was thể first etabolic cycle to be Vered, predating the description of the citric cle by 5 years. Hans Krebs along with Kurt Henseleit used their Warburg manometer (pictured) itor the use of carbon dioxide and ammonia in the synthesis of urea. In the presence of a slice , urea could be produced, but the reaction require e and citrulline. Since citrulline is not consumed during urse of the enzymatic cycle, but is rather regenerated, described citrulline as a "catalyst" of the process. H2N OH /hat do initiation of the urea cycle and initiation of NH2 eogenesis have in common? at is the first committed step of the urea cycle, what reactants are used, what product is ed, where does it take place, how is it allosterically regulated, and how is the allosteric regulator ed? cribe the reversible steps in the urea cycle, including the substrates, products, and enzymes. at are the energy-consuming steps of the urea cycle and what is the energetic cost of the urea n terms of ATP equivalents? How is this cost partially offset and what is the total net energetic the urea cycle?

Human Anatomy & Physiology (11th Edition)
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Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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4. The urea cycle was the first metabolic cycle to be discovered, predating the description of the citric
acid cycle by 5 years. Hans Krebs along with Kurt Henseleit used their Warburg manometer (pictured)
to monitor the use of carbon dioxide and ammonia in the synthesis of urea. In the presence of a slice
of liver, urea could be produced, but the reaction require
ornithine and citrulline. Since citrulline is not consumed during
the course of the enzymatic cycle, but is rather regenerated,
Krebs described citrulline as a “catalyst” of the process.
O
H₂N
(a) What do initiation of the urea cycle and initiation of
gluconeogenesis have in common?
OH
NH₂
(b) What is the first committed step of the urea cycle, what reactants are used, what product is
produced, where does it take place, how is it allosterically regulated, and how is the allosteric regulator
produced?
(c) Describe the reversible steps in the urea cycle, including the substrates, products, and enzymes.
(d) What are the energy-consuming steps of the urea cycle and what is the energetic cost of the urea
cycle in terms of ATP equivalents? How is this cost partially offset and what is the total net energetic
cost of the urea cycle?
Transcribed Image Text:4. The urea cycle was the first metabolic cycle to be discovered, predating the description of the citric acid cycle by 5 years. Hans Krebs along with Kurt Henseleit used their Warburg manometer (pictured) to monitor the use of carbon dioxide and ammonia in the synthesis of urea. In the presence of a slice of liver, urea could be produced, but the reaction require ornithine and citrulline. Since citrulline is not consumed during the course of the enzymatic cycle, but is rather regenerated, Krebs described citrulline as a “catalyst” of the process. O H₂N (a) What do initiation of the urea cycle and initiation of gluconeogenesis have in common? OH NH₂ (b) What is the first committed step of the urea cycle, what reactants are used, what product is produced, where does it take place, how is it allosterically regulated, and how is the allosteric regulator produced? (c) Describe the reversible steps in the urea cycle, including the substrates, products, and enzymes. (d) What are the energy-consuming steps of the urea cycle and what is the energetic cost of the urea cycle in terms of ATP equivalents? How is this cost partially offset and what is the total net energetic cost of the urea cycle?
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