Consider the malate dehydrogenase reaction, part of tricarboxylic acid cycle, shown below. malate + NAD+ oxaloacetate + NADH + H+ ΔGo ’ = 29.7 kJ/mol. It has been reported that the concentrations of NAD+ and NADH in yeast mitochondria were 20 mM and 0.3 mM, respectively. If we performed similar measurements and also determined that the concentration of malate in yeast mitochondria was 0.5 mM and that of oxaloacetate was 0.1 µM at pH 7.0 at 37˚C, use this information to calculate the equilibrium constant for the given reaction.
Consider the malate dehydrogenase reaction, part of tricarboxylic acid cycle, shown below. malate + NAD+ oxaloacetate + NADH + H+ ΔGo ’ = 29.7 kJ/mol. It has been reported that the concentrations of NAD+ and NADH in yeast mitochondria were 20 mM and 0.3 mM, respectively. If we performed similar measurements and also determined that the concentration of malate in yeast mitochondria was 0.5 mM and that of oxaloacetate was 0.1 µM at pH 7.0 at 37˚C, use this information to calculate the equilibrium constant for the given reaction.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Consider the malate dehydrogenase reaction, part of tricarboxylic acid cycle, shown below. malate + NAD+ oxaloacetate + NADH + H+ ΔGo ’ = 29.7 kJ/mol. It has been reported that the concentrations of NAD+ and NADH in yeast mitochondria were 20 mM and 0.3 mM, respectively. If we performed similar measurements and also determined that the concentration of malate in yeast mitochondria was 0.5 mM and that of oxaloacetate was 0.1 µM at pH 7.0 at 37˚C, use this information to calculate the equilibrium constant for the given reaction.
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