Consider the following phenotype for hemophilia, a recessive X-linked blood clotting disorder, in decendents of Queen Victoria. Victoria is thought to have been a carrier for the recessive hemophilia allele. What is the probability that Princess Irene is also a carrier? Albert Victoria (1819-1901) Helena Princess Leopold Duke of Edward Alice Beatrice ess rin VII of Hesse Christian Albany 도모오오오 모 Victoria Leopold Maurice Eugenie (wife of Alfonso XII) Princess Frederick (Alexandra) Alix Tsarina Alice of Athlone Kaiser George Wilhelm II V Irene Nikolas II
Consider the following phenotype for hemophilia, a recessive X-linked blood clotting disorder, in decendents of Queen Victoria. Victoria is thought to have been a carrier for the recessive hemophilia allele. What is the probability that Princess Irene is also a carrier? Albert Victoria (1819-1901) Helena Princess Leopold Duke of Edward Alice Beatrice ess rin VII of Hesse Christian Albany 도모오오오 모 Victoria Leopold Maurice Eugenie (wife of Alfonso XII) Princess Frederick (Alexandra) Alix Tsarina Alice of Athlone Kaiser George Wilhelm II V Irene Nikolas II
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
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Chapter1: The Human Body: An Orientation
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Transcribed Image Text:The image depicts a pedigree chart focusing on the inheritance of hemophilia, a recessive X-linked blood clotting disorder, within the descendants of Queen Victoria. The chart is used to illustrate genetic inheritance patterns to evaluate the probability that Princess Irene is a carrier of the hemophilia allele.
### Key Elements in the Pedigree:
- **Symbols:**
- Squares represent males.
- Circles represent females.
- Shaded icons indicate individuals affected by hemophilia.
- Unshaded icons indicate individuals who are unaffected.
- A half-shaded circle represents a known or potential carrier of the hemophilia allele.
### Family Overview:
- **Queen Victoria (1819-1901):**
- Listed at the top of the chart, she is presumed to have been a carrier of the hemophilia allele.
- **Direct Descendants:**
- Victoria's children include several male and female heirs, among whom some are carriers or affected by hemophilia.
- **Notable Descendants:**
- **Leopold, Duke of Albany:** Identified as affected by hemophilia (shaded square).
- **Frederick:** Identified as affected (shaded square).
- **Maurice:** Another male descendant who is affected (shaded square).
- **Princess Irene:**
- The subject of interest in the question, she is a daughter of Alice of Hesse. The potential for her to be a carrier is indicated by her connection to Victoria's line, but her circle remains unshaded suggesting an unknown carrier status.
### Genetic Context:
- **Recessive X-linked Inheritance:**
- Males (XY) inheriting the affected X chromosome will manifest the disorder.
- Females (XX) may be carriers if they inherit one affected X chromosome, potentially passing it to their offspring without showing symptoms themselves.
### Question Focus:
- **Probability of Princess Irene Being a Carrier:**
- This requires evaluating the potential transmission of the recessive allele from her mother, a daughter of a known carrier (Queen Victoria), and the possibility of inheriting an affected X chromosome.
This educational illustration is used to teach genetic inheritance patterns and the complexities of X-linked disorders in royal lineages.
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