Susan Husband healthy Affected healthy Affected

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter11: Genome Alterations: Mutation And Epigenetics
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Problem 16QP: Familial retinoblastoma, a rare autosomal dominant defect, arose in a large family that had no prior...
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what are the possible genotypes for susan and her husband in the following pedigree
**Pedigree of Sickle Cell Anemia in the Miller Family**

The image above represents a pedigree chart detailing the inheritance of sickle cell anemia within the Miller family. Pedigree charts are a visual tool used in genetics to illustrate the occurrence and appearance of phenotypes of a particular gene or organism and its ancestors from one generation to the next.

### Symbols Key:
- **Squares (□)** represent male family members.
- **Circles (○)** represent female family members.
- **Filled symbols (■ or ●)** indicate individuals affected by sickle cell anemia.
- **Empty symbols (□ or ○)** indicate individuals not affected by sickle cell anemia.

### Generations:
The pedigree chart is divided into three generations:

**First Generation:**
- This generation includes one male who is affected (black square) and his female partner who is unaffected (white circle).

**Second Generation:**
- The second generation consists of four children:
  - Two affected males (black squares).
  - One affected female (black circle).
  - One unaffected male (white square).

**Third Generation:**
- The third generation includes six children from two pairs:
  - The first pair comprises one unaffected male married to an unaffected female (labeled as Susan).
  - Their children consist of one healthy (unaffected) boy (white square), one affected girl (black circle), one unaffected girl (white circle), and one affected boy (black square), totaling four children.
  - The second pair has one affected male (black square) married to an unaffected female (white circle).

The pedigree chart clearly demonstrates an autosomal recessive pattern of inheritance for sickle cell anemia. This means that both copies of the gene in each cell have mutations for an individual to be affected. Individuals with just one copy of the mutated gene (carriers) are typically not affected but can pass the mutation to their offspring.
Transcribed Image Text:**Pedigree of Sickle Cell Anemia in the Miller Family** The image above represents a pedigree chart detailing the inheritance of sickle cell anemia within the Miller family. Pedigree charts are a visual tool used in genetics to illustrate the occurrence and appearance of phenotypes of a particular gene or organism and its ancestors from one generation to the next. ### Symbols Key: - **Squares (□)** represent male family members. - **Circles (○)** represent female family members. - **Filled symbols (■ or ●)** indicate individuals affected by sickle cell anemia. - **Empty symbols (□ or ○)** indicate individuals not affected by sickle cell anemia. ### Generations: The pedigree chart is divided into three generations: **First Generation:** - This generation includes one male who is affected (black square) and his female partner who is unaffected (white circle). **Second Generation:** - The second generation consists of four children: - Two affected males (black squares). - One affected female (black circle). - One unaffected male (white square). **Third Generation:** - The third generation includes six children from two pairs: - The first pair comprises one unaffected male married to an unaffected female (labeled as Susan). - Their children consist of one healthy (unaffected) boy (white square), one affected girl (black circle), one unaffected girl (white circle), and one affected boy (black square), totaling four children. - The second pair has one affected male (black square) married to an unaffected female (white circle). The pedigree chart clearly demonstrates an autosomal recessive pattern of inheritance for sickle cell anemia. This means that both copies of the gene in each cell have mutations for an individual to be affected. Individuals with just one copy of the mutated gene (carriers) are typically not affected but can pass the mutation to their offspring.
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