Compound A has a partition coefficient (Kp) of 3.5. If you start with a solution of 150 mg of compound A in 1.0 mL water, the amount that is recovered by extraction with one 300 uL portion of ether is 76.8 mg. How much A would be recovered after extraction with two 150 uL portions of ether instead of one 300 uL portion of ether?

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Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
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Conventional wisdom says that it’s always better to extract with several small portions rather than one large portion. Is this really true? Compound A has a partition coefficient (Kp) of 3.5. If you start with a solution of 150 mg of compound A in 1.0 mL water, the amount that is recovered by extraction with one 300 uL portion of ether is 76.8 mg. How much A would be recovered after extraction with two 150 uL portions of ether instead of one 300 uL portion of ether?

K₁=
Kp
solubility in organic solvent
solubility in water
K₂=3.5=
P
x mg A ở
300 μL ether
-
-150-x mg A
1000μL water.
Solve for x...
x = 76.8 mg A
Ö
Transcribed Image Text:K₁= Kp solubility in organic solvent solubility in water K₂=3.5= P x mg A ở 300 μL ether - -150-x mg A 1000μL water. Solve for x... x = 76.8 mg A Ö
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