-CO̟Et OAc -co,Et OCH3 (i) dil aq. HCI, 70 °C Lipase PS, t-BUOCH3, 168 h OH он (S)-2 (iї) K-СОз, 168 h OCH3 -CO2Et 1 CO̟Et Eto-P EtO ОН ОАс 3 (R/S)-2 Figure 2.2: Synthesis of (R/S)-2 and kinetic resolution with lipase PS.
-CO̟Et OAc -co,Et OCH3 (i) dil aq. HCI, 70 °C Lipase PS, t-BUOCH3, 168 h OH он (S)-2 (iї) K-СОз, 168 h OCH3 -CO2Et 1 CO̟Et Eto-P EtO ОН ОАс 3 (R/S)-2 Figure 2.2: Synthesis of (R/S)-2 and kinetic resolution with lipase PS.
Chemistry
10th Edition
ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
Related questions
Question
Which new signal(s) in compound 3 would you expect not to be in (R/S)-2 for H NMR analysis? What functionality does this correspond to? Thank you :) (Mechanism included to show what (R/S)-2 and 3 are.)
Transcribed Image Text:-CO̟Et
OAc
-co,Et
OCH3
(i) dil aq. HCI, 70 °C
Lipase PS,
t-BUOCH3, 168 h
OH
он (S)-2
(iї) K-СОз, 168 h
OCH3
-CO2Et
1
CO̟Et
Eto-P
EtO
ОН
ОАс 3
(R/S)-2
Figure 2.2: Synthesis of (R/S)-2 and kinetic resolution with lipase PS.
Expert Solution
Step 1
We have to identify the new signal(s) in compound 3 would you expect not to be in (R/S)-2 for H NMR analysis as follows in step 2:
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