Clinical Case Study Nutrition and Metabolism Kyle Boulard, a 35-year-old male, is believed to be one of the primary causes of the accident on Route 91. Passengers on the bus reported that Mr. Boulard was dearly intoxicated when he boarded the bus. According to these reports, Mr. Boulard behaved erratically, appeared disoriented, and left his seat and staggered down the aisle. Just prior to the accident, he had stumbled into the driver's compartment. Paramedics found Mr. Boulard in a disoriented state when they arrived on the scene, but noted only minor injuries. A "fruity acetone combined with alcohol" smell was noted on his breath. What follows is a summary of the notable test results: General Blood Urine ВР: 95/58 рH: 7.1 Odor: "fruity acetone" HR: 110 Glucose: 345 mg/dl pH: 4.3 Ketone bodies: Glucose: strongly positive 22 mg/dl Blood alcohol: 110 mg/dl
1. Urine glucose is usually negative. Using a table of reference values for blood and urine tests, look up normal values for blood pH, blood glucose, blood ketone bodies, and urine pH, and identify whether each test result is normal or abnormal. 2. A “fruity acetone combined with alcohol” smell was detected in Mr. Boulard’s breath, and in his urine. Which substance is producing the “fruity acetone” smell? 3. Where in the body are ketone bodies produced? What energy source does the body use to produce these substances? 4. The production of large amounts of ketone bodies is often seen when glucose is not readily available as an energy source (e.g., in starvation). In Mr. Boulard’s case, large amounts of glucose are in the blood. Explain why his body is producing
large amounts of glucose. 5. Explain how the pH of Mr. Boulard’s blood and urine is related to the ketone bodies measured in each of these fluids.

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