Can you explain the various options and how did you come to the answer? How to know whether histine is required in protonated or unprotected state? Does the level of the pH affect the result?
Can you explain the various options and how did you come to the answer? How to know whether histine is required in protonated or unprotected state? Does the level of the pH affect the result?
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
Can you explain the various options and how did you come to the answer? How to know whether histine is required in protonated or unprotected state? Does the level of the pH affect the result?
![Often found in enzymes. Depending on the pH of its environment, sometimes
histidine is neutral and at other times it acquires a proton and becomes positively charged. Consider an
enzyme with a histidine side chain that is known to have an important role in the function of the enzyme. It is
not clear whether this histidine is required in its protonated or its unprotonated state. To answer this
(traxeut to %) Avesse
40
→
2
6
$ 9 10](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2F637a8243-98d2-45ca-8dd1-4e9d7d0f97ca%2Fdefc8878-9d31-4742-9042-386435586e5f%2Fk0akxfa.jpeg&w=3840&q=75)
Transcribed Image Text:Often found in enzymes. Depending on the pH of its environment, sometimes
histidine is neutral and at other times it acquires a proton and becomes positively charged. Consider an
enzyme with a histidine side chain that is known to have an important role in the function of the enzyme. It is
not clear whether this histidine is required in its protonated or its unprotonated state. To answer this
(traxeut to %) Avesse
40
→
2
6
$ 9 10
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