Briefly explain the direct effect (i.e., not via hormones) glucose has on the enzyme, referring to the structure of the enzyme. b. Imagine you develop a drug that targets glycogen synthase kinase as a treatment for Type 2 diabetes. You need to determine if this drug activates or inhibits glycogen synthase kinase? What effect should the drug have on the phosphorylation state and activity of glycogen synthase? Explain in detail your decision. c. Would protein phosphatase 1 (PP1) have to be active or inactive for this drug to be effective?
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Answer the following questions about Glygogen
a. After a carbohydrate-filled breakfast, your blood glucose levels increase. How does glucose affect liver glycogen phosphorylase activity? Briefly explain the direct effect (i.e., not via hormones) glucose has on the enzyme, referring to the structure of the enzyme.
b. Imagine you develop a drug that targets glycogen synthase kinase as a treatment for Type 2 diabetes. You need to determine if this drug activates or inhibits glycogen synthase kinase? What effect should the drug have on the phosphorylation state and activity of glycogen synthase? Explain in detail your decision.
c. Would protein phosphatase 1 (PP1) have to be active or inactive for this drug to be effective? Explain the rationale for your response; be sure to refer to the function of PP1 in your response.
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