Below is a pedigree of a family with a history of Best disease (or vitelliform macular dystrophy). All members of this family underwent ASO testing using two different ligonucleotides (ASO 1 and ASO 2): one that hybridizes to the only known mutation that leads to Best disease and one that hybridizes to the wild-type gene sequence in the same region. From the information you have, how is Best disease most likely inherited? L II. III. autosomal dominant autosomal recessive x-linked recessive x-linked dominant you cannot determine ASO 1 ASO 2 1-1 1-2 11-1 11-2 11-3
Below is a pedigree of a family with a history of Best disease (or vitelliform macular dystrophy). All members of this family underwent ASO testing using two different ligonucleotides (ASO 1 and ASO 2): one that hybridizes to the only known mutation that leads to Best disease and one that hybridizes to the wild-type gene sequence in the same region. From the information you have, how is Best disease most likely inherited? L II. III. autosomal dominant autosomal recessive x-linked recessive x-linked dominant you cannot determine ASO 1 ASO 2 1-1 1-2 11-1 11-2 11-3
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:Below is a pedigree of a family with a history of Best disease (or vitelliform macular dystrophy). All members of this family underwent ASO testing using two different
oligonucleotides (ASO 1 and ASO 2): one that hybridizes to the only known mutation that leads to Best disease and one that hybridizes to the wild-type gene sequence in the
same region. From the information you have, how is Best disease most likely inherited?
1.
II.
III.
0 0 0 0 0
1
?
autosomal dominant
autosomal recessive
x-linked
recessive
x-linked dominant
you cannot determine
ASO 1
ASO 2
1-1
1-2 II-1 11-2 11-3
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