B-1. The results indicate that depression can be caused by levels of serotonin receptors that are (higher than normal) (lower than normal) (neither – no evidence here for any effect on depression) (higher or lower but can't tell which). B-2. If a depressed person does not respond to SSRIs, the person should (stop taking NSAIDs) (start taking NSAIDs) (start or stop, but I'm not sure which) (do something else – the level of NSAID should make no difference). Explain your answer to C C. The most likely role of p11 is regulation of (exocytosis) (endocytosis) (translation) (transcription).
Serotonin is a neurotransmitter that is a small, soluble molecule. P11 (a small protein) is required for transport of serotonin receptors to the cell surface. Assume for this problem that p11 affects transport of serotonin receptors only, and that it does not affect transport of any other proteins (a simplification). Depressed people seem to have low levels of p11; treatments that improve mood increase the expression of the p11 gene. NSAIDs (aspirin, ibuprofen, etc.) seem to decrease expression of p11. SSRIs (selective serotonin reuptake inhibitors) decrease re-uptake of serotonin at synapses. Some depressed patients are helped by SSRIs, but some are not.
Explain both parts of B.
B-1. The results indicate that depression can be caused by levels of serotonin receptors that are
(higher than normal) (lower than normal) (neither – no evidence here for any effect on depression) (higher or lower but can't tell which).
B-2. If a depressed person does not respond to SSRIs, the person should
(stop taking NSAIDs) (start taking NSAIDs) (start or stop, but I'm not sure which)
(do something else – the level of NSAID should make no difference).
Explain your answer to C
C. The most likely role of p11 is regulation of (exocytosis) (endocytosis) (translation) (transcription).
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