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ATP is synthesized from ADP, P, and a proton on the matrix side of the in- ner mitochondrial membrane. We will refer to the matrix side as the "inside" of the inner mitochondrial membrane (IMM). (a) H* transport from the outside of the IMM into the matrix drives this process. The pH inside the matrix is 8.2, and the outside is more acidic by 0.8 pH units. Assuming the IMM membrane potential is 168 mV (inside negative), calculate AG for the transport of 1 mol of H* across the IMM into the matrix at 37 °C: Houtside) Hinside) (b) Assume three mol H* must be translocated to synthesize one mol ATP by coupling of the following reactions: ADP + P, + Hinskde) ATP + H,O(ATP synthesis) 3Hinside)(proton transport) 3Houtside) Write the overall reaction for ATP synthesis coupled to H* transport [and use this equation for part (c)]: (c) Assume three mol H* must be translocated to synthesize one mol ATP as described in part (b) above. Given the following steady-state concentrations: ATP=2.70 mM and P, = 5.20 mM, the membrane potential A = 168 mV (inside negative), and the pH values in part (a), calculate the steady-state concentration of ADP at 37 °C when AG = -11.7 kJ/mol.

ATP is synthesized from ADP, P, and a proton on the matrix side of the in- ner mitochondrial membrane. We will refer to the matrix side as the "inside" of the inner mitochondrial membrane (IMM). (a) H* transport from the outside of the IMM into the matrix drives this process. The pH inside the matrix is 8.2, and the outside is more acidic by 0.8 pH units. Assuming the IMM membrane potential is 168 mV (inside negative), calculate AG for the transport of 1 mol of H* across the IMM into the matrix at 37 °C: Houtside) Hinside) (b) Assume three mol H* must be translocated to synthesize one mol ATP by coupling of the following reactions: ADP + P, + Hinskde) ATP + H,O(ATP synthesis) 3Hinside)(proton transport) 3Houtside) Write the overall reaction for ATP synthesis coupled to H* transport [and use this equation for part (c)]: (c) Assume three mol H* must be translocated to synthesize one mol ATP as described in part (b) above. Given the following steady-state concentrations: ATP=2.70 mM and P, = 5.20 mM, the membrane potential A = 168 mV (inside negative), and the pH values in part (a), calculate the steady-state concentration of ADP at 37 °C when AG = -11.7 kJ/mol.

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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ATP is synthesized from ADP, P, and a proton on the matrix side of the in- ner mitochondrial membrane. We will refer to the matrix side as the "inside" of the inner mitochondrial membrane (IMM). (a) H* transport from the outside of the IMM into the matrix drives this process. The pH inside the matrix is 8.2, and the outside is more acidic by 0.8 pH units. Assuming the IMM membrane potential is 168 mV (inside negative), calculate AG for the transport of 1 mol of H* across the IMM into the matrix at 37 °C: Houtside) Hinside) (b) Assume three mol H* must be translocated to synthesize one mol ATP by coupling of the following reactions: ADP + P, + Hinskde) ATP + H,O(ATP synthesis) 3Hinside)(proton transport) 3Houtside)
Transcribed Image Text:ATP is synthesized from ADP, P, and a proton on the matrix side of the in- ner mitochondrial membrane. We will refer to the matrix side as the "inside" of the inner mitochondrial membrane (IMM). (a) H* transport from the outside of the IMM into the matrix drives this process. The pH inside the matrix is 8.2, and the outside is more acidic by 0.8 pH units. Assuming the IMM membrane potential is 168 mV (inside negative), calculate AG for the transport of 1 mol of H* across the IMM into the matrix at 37 °C: Houtside) Hinside) (b) Assume three mol H* must be translocated to synthesize one mol ATP by coupling of the following reactions: ADP + P, + Hinskde) ATP + H,O(ATP synthesis) 3Hinside)(proton transport) 3Houtside)
Write the overall reaction for ATP synthesis coupled to H* transport [and use this equation for part (c)]: (c) Assume three mol H* must be translocated to synthesize one mol ATP as described in part (b) above. Given the following steady-state concentrations: ATP=2.70 mM and P, = 5.20 mM, the membrane potential A = 168 mV (inside negative), and the pH values in part (a), calculate the steady-state concentration of ADP at 37 °C when AG = -11.7 kJ/mol.
Transcribed Image Text:Write the overall reaction for ATP synthesis coupled to H* transport [and use this equation for part (c)]: (c) Assume three mol H* must be translocated to synthesize one mol ATP as described in part (b) above. Given the following steady-state concentrations: ATP=2.70 mM and P, = 5.20 mM, the membrane potential A = 168 mV (inside negative), and the pH values in part (a), calculate the steady-state concentration of ADP at 37 °C when AG = -11.7 kJ/mol.
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