Assume you have a solution containing the pyruvate dehydrogenase complex and all the enzymes of the TCA cycle, but none of the metabolic intermedi- ates. When you supplement this solution with 5 umoles each of pyruvate, oxaloacetate, coenzyme A, NAD*, FAD, GDP, and P,, you find that 5 umoles of CO, are evolved and then the reaction stops. When you add alcohol dehy- drogenase and its substrate acetaldehyde, additional CO, is produced. (a) How do you explain this result? (b) How many umoles of acetaldehyde are required to allow complete oxida- tion of the pyruvate to 15 umoles of CO,?

Assume you have a solution containing the pyruvate dehydrogenase complex and all the enzymes of the TCA cycle, but none of the metabolic intermedi- ates. When you supplement this solution with 5 umoles each of pyruvate, oxaloacetate, coenzyme A, NAD*, FAD, GDP, and P,, you find that 5 umoles of CO, are evolved and then the reaction stops. When you add alcohol dehy- drogenase and its substrate acetaldehyde, additional CO, is produced. (a) How do you explain this result? (b) How many umoles of acetaldehyde are required to allow complete oxida- tion of the pyruvate to 15 umoles of CO,?

Chemistry

10th Edition

ISBN:9781305957404

Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Publisher:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste

Chapter1: Chemical Foundations

Section: Chapter Questions

Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...

See similar textbooks

Similar questions

. Some anaerobic bacteria use an alternative pathway for glucose catabolism, shown below, that converts glucose to acetate rather than to pyruvate. The first part of this pathway (glucose to fructose- 1,6-bisphosphate) is identical to the glycolytic pathway. In the second part of the alternative pathway, Enzymes 1-6 all have mechanisms/activities analogous to enzymes in glycolysis. Note that
A few hours after the death of an animal, the corpse will stiffen as a result of continued contraction of muscle tissue (this state is called rigor mortis). This phenomenon is the result of the loss of ATP production in muscle tissue.(a) Consult as shown and describe, in terms of the six-step model of muscle contraction, how a lack of ATP in sarcomeres would result in rigor mortis.(b) The Ca2+ transporter in sarcomeres that keeps the [Ca2+]∼10-7 Mrequires ATP to drive transport of Ca2+ ions across the membrane of thesarcoplasmic reticulum. How would a loss of this Ca2+ transport functionresult in the initiation of rigor mortis?(c) Rigor mortis is maximal at ∼12 hrs after death and by 72 hrs is nolonger observed. Propose an explanation for the disappearance of rigormortis after 12 hrs.
What is true about Na+/K+ ATPase? 3 moles of Na+ ion move out of the cell for every 2 moles K+ moving into cell Energy is required to pump ions against concentration gradient. It is an example of active transport All of the above
Like all chemical reactions, the glycolytic pathway can be expressed as a balanced equation showing reactants on the left side of the equation and products on the right. The equations below describe (a) aerobic glycolysis and (b) anaerobic glycolysis (lactic acid fermentation). However, they are not balanced (i.e., they lack the correct stoichiometry). Complete the equations using the correct stoichiometry, assuming that each reaction starts with one molecule of glucose. glucose + ADP + Pi + NAD+ --> pyruvate + ATP + NADH + H+ glucose + ADP + Pi --> lactate + ATP
Help with both please
Depending on the method you are using, the method for measuring lactate dehydrogenase either oxidizes lactate to pyruvate or reduces pyruvate to lactate. The biggest factor which influences the direction of the reaction is Question 55 options: A) pH B) presence of coenzyme NAD+ C) amount of LDH in sample D) reaction temperature
c. What is the equilibrium ratio of ATP to ADP if the ratio of creatine phosphate to creatine is 0.20?
Label the energy diagram for the reaction with and without lactase energy of activation without lactase lactose and water glucose and galactose energy of activation with lactase