Hydrolysis of ATP is favorable (AGo' = -30.5 kJ/mol), but the addition of inorganic phosphate (Pi) to glucose to yield glucose-6-phosphate, the first step in glycolysis, is unfavorable (AGo' = +13.8 kJ/mol). Show how these two reactions. can be coupled to favor formation of glucose-6-phosphate and allow glycolysis to proceed. Include the overall AGo' for the reaction.
Hydrolysis of ATP is favorable (AGo' = -30.5 kJ/mol), but the addition of inorganic phosphate (Pi) to glucose to yield glucose-6-phosphate, the first step in glycolysis, is unfavorable (AGo' = +13.8 kJ/mol). Show how these two reactions. can be coupled to favor formation of glucose-6-phosphate and allow glycolysis to proceed. Include the overall AGo' for the reaction.
Chemistry
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ISBN:9781305957404
Author:Steven S. Zumdahl, Susan A. Zumdahl, Donald J. DeCoste
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Chapter1: Chemical Foundations
Section: Chapter Questions
Problem 1RQ: Define and explain the differences between the following terms. a. law and theory b. theory and...
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Organic Chemistry of Metabolic Pathways
Metabolic pathways allude to the arrangement of chemical catalyzed reactions that lead to the transformation of a substance into the final product. Metabolic pathways incorporate a progression of reaction where the substrate is changed continuously and the transitional metabolites are persistently recovered.
Glucogenesis
Glucogenesis is a metabolic pathway in which glucose is produced from carbon substrates that are not carbohydrates. This process is observed in plants, animals, fungi, bacteria and other micro organisms. The general definition for glucogenesis or gluconeogenesis is as follows,
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
Transcribed Image Text:Hydrolysis of ATP is favorable (AGo' =
=
-30.5 kJ/mol), but the addition of
inorganic phosphate (Pi) to glucose to
yield glucose-6-phosphate, the first step
in glycolysis, is unfavorable (AGo' = +13.8
kJ/mol). Show how these two reactions
can be coupled to favor formation of
glucose-6-phosphate and allow glycolysis
to proceed. Include the overall AGo' for
the reaction.
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