GFPGFPGFPGFPGFPPHGFP:DOK1 constructs150150150PTB250250250350430 481430430 481GFP microscopykidney cells-LMB+LMB*LMB is a drug thatinhibits export ofproteins via nuclear poreAnswer on Canvas:1) Where doesDOK1 localize inthe cell?2) Which region ofDOK1 contains anuclear exportsignal?

Proteins, transfer RNA, and assembled ribosomal subunits are exported from the nucleus due to…

Answered: Answer on Canvas: 1) Where does DOK1…

Human Anatomy & Physiology (11th Edition)

11th Edition

ISBN:9780134580999

Author:Elaine N. Marieb, Katja N. Hoehn

Publisher:Elaine N. Marieb, Katja N. Hoehn

Chapter1: The Human Body: An Orientation

Section: Chapter Questions

Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...

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This inhibatory kinase phosphorylates an inactive M-Cdk. a) M-kinase b) Wee1 c) CAK d) Cdc25
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Imagine that you created a cell that over-expresses a truncated version of its extrinsic pathway initiator caspase. This protein contains the caspase's DED, but none of the caspase's protease domains. This truncated version is present as an extra copy in addition to the WT copy. In 1-2 sentences, explain what the outcome would be on extrinsic apoptosis (i.e. would it be a positive/negative regulator/have no effect) and why.
When the gene encoding a certain cellular kinase is deleted, the resulting mutant cells arrest in the cell cycle and do not divide. These mutants can be rescued when a gene encoding an N-terminal GFP fusion of the protein is expressed, but not when a gene encoding a C-terminal GFP fusion is expressed. Which fusion protein is appropriate to use in studying cellular localization and activity? Explain why.
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Q40
Zeb1 encodes a transcription factor that activates expression of genes that help cells migrate (move to different parts of the body) during embryogenesis. Zeb1 is not expressed in most adult tissues, but can undergo a gain of function mutation in some tumors. Which change is likely to result from a gain of function mutation in Zeb1? a) sustaining proliferative signalling b) activating invasion and metastasis O c) deregulating cellular energetics O d) resisting cell death
Do GPCR ligands physically enter the cell through their receptor? a) Yes b) No
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Answer on Canvas: 1) Where does DOK1 localize in the cell? 2) Which region of DOK1 contains a nuclear export signal?