Answer choices for A: deletion, transversion, insertion, transition Answer choices for B: nonsense, framshift, silent, in-frame, missense Answer choices for C: mismatch repair, homologous recombination repair, nucleotide excision repair, base excision repair, photo reactivation repair, translesion snythesis, nonhomologous end joining Answer choices for D: conditional, loss-of-function, neutral, gain-of-function, lethal Answer choices for E: bottom, top Answer choices for F: 5' UTR, exons, stop codon, 3' UTR, introns

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Answer choices for A: deletion, transversion, insertion, transition

Answer choices for B: nonsense, framshift, silent, in-frame, missense

Answer choices for C: mismatch repair, homologous recombination repair, nucleotide excision repair, base excision repair, photo reactivation repair, translesion snythesis, nonhomologous end joining

Answer choices for D: conditional, loss-of-function, neutral, gain-of-function, lethal

Answer choices for E: bottom, top

Answer choices for F: 5' UTR, exons, stop codon, 3' UTR, introns

The wildtype version of a very short gene is:
DNA:
5'-GTACGGATGCTTTACGTAGGGTGA-3'
3'-CATGCCTACGAAATGCATCCCACT-5'
and is translated to:
N-Met-Leu-Tyr-Val-Gly-C
Researchers discover a mutant version of this gene with the following amino acid sequence:
N-Met-Pro-Tyr-Val-Gly-C
A. The type of nucleotide mutation that occurred in the mutant sequence is a
[Select]
B. The type of amino acid mutation that occurred in the mutant sequence is a
[Select]
✓ mutation.
C. This mutation resulted from a misincorporation that went unnoticed by DNA polymerase during
DNA replication. Which DNA repair system was tasked with recognizing and correcting this error?
[Select]
D. Individuals possessing this mutant polypeptide show incomplete thumb growth. Due to its
phenotypic effects, this is a [Select]
✓ mutation.
E. Which DNA strand is the coding strand? Top or bottom? [Select ]
F. Which of the following components would you find in this gene's preliminary mRNA transcript, but
not in its mature mRNA transcript? [Select]
Transcribed Image Text:The wildtype version of a very short gene is: DNA: 5'-GTACGGATGCTTTACGTAGGGTGA-3' 3'-CATGCCTACGAAATGCATCCCACT-5' and is translated to: N-Met-Leu-Tyr-Val-Gly-C Researchers discover a mutant version of this gene with the following amino acid sequence: N-Met-Pro-Tyr-Val-Gly-C A. The type of nucleotide mutation that occurred in the mutant sequence is a [Select] B. The type of amino acid mutation that occurred in the mutant sequence is a [Select] ✓ mutation. C. This mutation resulted from a misincorporation that went unnoticed by DNA polymerase during DNA replication. Which DNA repair system was tasked with recognizing and correcting this error? [Select] D. Individuals possessing this mutant polypeptide show incomplete thumb growth. Due to its phenotypic effects, this is a [Select] ✓ mutation. E. Which DNA strand is the coding strand? Top or bottom? [Select ] F. Which of the following components would you find in this gene's preliminary mRNA transcript, but not in its mature mRNA transcript? [Select]
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