An article in Biotechnology Progress [“Optimization of Conditions for Bacteriocin Extraction in PEG/Salt Aqueous Two-Phase Systems Using Statistical Experimental Designs” (2001, Vol. 17, pp. 366–368)] reported an experiment to investigate and optimize the extraction of nisin in aqueous two-phase systems (ATPS). Nisin recovery was the dependent variable (y). The two regressor variables were the concentration (%) of PEG 4000 (indicated as x1) and the concentration (%) of Na2SO4 (indicated as x2). The data is shown below. a) Find the fit parameters of the proposed model. b) Establish, b

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An article in Biotechnology Progress [“Optimization of Conditions for Bacteriocin Extraction in PEG/Salt Aqueous Two-Phase Systems Using Statistical Experimental Designs” (2001, Vol. 17, pp. 366–368)] reported an experiment to investigate and optimize the extraction of nisin in aqueous two-phase systems (ATPS). Nisin recovery was the dependent variable (y). The two regressor variables were the concentration (%) of PEG 4000 (indicated as x1) and the concentration (%) of Na2SO4 (indicated as x2). The data is shown below.

a) Find the fit parameters of the proposed model.

b) Establish, by means of a hypothesis test, if the regression is significant.

c) State, if the regression coefficients are significant.

d) Evaluate R2 as well as R_adjusted^2.

e) Construct and analyze the residual plot.

X1
X2
y
13
11
62,8739
15
11
76,1328
13
13
87,4667
15
13
102,3236
14
12
76,1863
14
12
77,5287
14
12
76,7824
14
12
77,4381
14
12
78,7417
Transcribed Image Text:X1 X2 y 13 11 62,8739 15 11 76,1328 13 13 87,4667 15 13 102,3236 14 12 76,1863 14 12 77,5287 14 12 76,7824 14 12 77,4381 14 12 78,7417
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