Activity of phosphofructokinase-1 (PFK-1) is tightly-controlled by allosteric regulators. Identify the two positive and two negative allosteric regulators of PFK-1 activity from the list of biomolecules below. In addition, identify the two biomolecules in the list that do not function as allosteric regulators of PFK-1. Type of PFK-1 Regulation A. Positive allosteric regulation Biomolecules 1. fructose- 1,6-BP B. Negative allosteric 2. citrate regulation C. Not an allosteric 3. ATP regulator 4. ADP 5. glucose- 6P 6. fructose-
Activity of phosphofructokinase-1 (PFK-1) is tightly-controlled by allosteric regulators. Identify the two positive and two negative allosteric regulators of PFK-1 activity from the list of biomolecules below. In addition, identify the two biomolecules in the list that do not function as allosteric regulators of PFK-1. Type of PFK-1 Regulation A. Positive allosteric regulation Biomolecules 1. fructose- 1,6-BP B. Negative allosteric 2. citrate regulation C. Not an allosteric 3. ATP regulator 4. ADP 5. glucose- 6P 6. fructose-
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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Transcribed Image Text:**Activity of Phosphofructokinase-1 (PFK-1) and Allosteric Regulation**
Phosphofructokinase-1 (PFK-1) plays a critical role in glycolysis and is tightly controlled by allosteric regulators. The task is to identify two positive and two negative allosteric regulators of PFK-1 activity from the list of biomolecules provided. Additionally, identify two biomolecules in the list that do not function as allosteric regulators of PFK-1.
**Types of PFK-1 Regulation**
**A. Positive Allosteric Regulation**
- These are molecules that enhance the activity of PFK-1.
**B. Negative Allosteric Regulation**
- These molecules inhibit the activity of PFK-1.
**C. Not an Allosteric Regulator**
- These molecules do not affect PFK-1 regulation.
**Biomolecules**
1. Fructose-1,6-bisphosphate (fructose-1,6-BP)
2. Citrate
3. ATP
4. ADP
5. Glucose-6-phosphate (glucose-6P)
6. Fructose-2,6-bisphosphate (fructose-2,6-BP)

Transcribed Image Text:This image contains a matching exercise related to allosteric regulation, a concept in biochemistry. It is likely intended for educational purposes.
### Categories and Options:
**A. Positive allosteric regulation**
**B. Negative allosteric regulation**
**C. Not an allosteric regulator**
### Options:
1. citrate
2. ATP
3. fructose-2,6-BP
4. AMP
5. glucose-6P
6. fructose-2,6-BP
### Answer Selections:
- **Option 1:** \(A: 4,6; \ B: 1,3; \ C: 2,5\)
- **Option 2:** \(A: 3,6; \ B: 2,4; \ C: 1,5\)
- **Option 3:** \(A: 4,6; \ B: 2,3; \ C: 1,5\)
- **Option 4:** \(A: 4,5; \ B: 2,3; \ C: 1,6\)
- **Option 5:** \(A: 3,5; \ B: 1,4; \ C: 2,6\)
This exercise requires students to match metabolites with their role in allosteric regulation based on the provided categories. Each option presents a different combination for categorizing the substances.
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