ACTIVITY 4:  Multiple alleles and ABO blood groups   Karl Landsteiner discovered the ABO blood groups in 1900.  He found that glycoproteins called antigens A and B may be found on the surface of human red blood cells.  People with type A antigens have blood type A; people with B antigens have blood type B, people with both A and B antigens have blood type AB and people with neither antigen have blood type O.  These blood types are important because if a person receives a blood transfusion from someone who has red blood cells with foreign antigens, serious injury or death may result.   A person with blood type AB may safely receive blood of which type(s)? ___     A person with blood type A may safely receive blood of which type(s)? __     A person with blood type O may safely receive blood of which type(s)?__

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ACTIVITY 4:  Multiple alleles and ABO blood groups

 

Karl Landsteiner discovered the ABO blood groups in 1900.  He found that glycoproteins called antigens A and B may be found on the surface of human red blood cells.  People with type A antigens have blood type A; people with B antigens have blood type B, people with both A and B antigens have blood type AB and people with neither antigen have blood type O.  These blood types are important because if a person receives a blood transfusion from someone who has red blood cells with foreign antigens, serious injury or death may result.

 

A person with blood type AB may safely receive blood of which type(s)? ___

 

 

A person with blood type A may safely receive blood of which type(s)? __

 

 

A person with blood type O may safely receive blood of which type(s)?__

 

 

 

 

The gene which controls ABO blood type has 3 alleles.  Two of the alleles are co-dominant

(IA and IB), and the third is recessive (i).

 

What is the genotype of a person with type AB blood? ___

 

What are the possible genotypes of a person with A blood?  ___

 

What about type B? ___

 

What about type O? ___

 

 

A. Do a Punnett square for a cross between a woman with blood type O and a man with type AB.

 

 

​​​​​​​

 

 

 

 

 

 

What are the genotypes of the offspring? ________________

 

Phenotypes? ________________

 

 

 

 

 

B. A woman sues for support of her child.  The mother has blood type A, the child has type O,

and the man has blood type B.  

Could he be the father of her child?  Yes or No ?    ___________

 

Show the Punnett square (male gametes on top, female on left): 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

What is % chance of offspring having type O blood? Explain in a short sentence:

 

 

 

 

 

 

C. With the same mother (type A) and child (type O) as above,

 

could a man with type AB blood be the father? Yes or No ?    ___________

 

Show the Punnett square (male gametes on top, female on left):

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

What is % chance of offspring having type O blood? Explain in a short sentence:

 

 

 

 

 

 

 

 

 

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