• (a) The kinetic data given below are for the reaction catalyzed by prostaglandin endoperoxide synthase. Focusing here on the first two columns, determine the Vmax and Km of the enzyme. (b) Ibuprofen is an inhibitor of prostaglandin endoperoxide synthase. By inhibiting the synthesis of prostaglandins, ibuprofen reduces inflammation and pain. Using the data in the first and third columns of the table, determine the type of inhibition that ibuprofen exerts on prostaglandin endoperoxi' Rate of formation of PGG, with 10 mg/mL ibuprofen (mm/min) Rate of formation [Arachidonic acid) (тм) of PGG2 (mm/min) 0.5 23.5 16.67 1.0 32.2 25.25 1.5 36.9 30.49 2.5 41.8 44.0 37.04 38.91 3.5
Electron Transport Chain
The electron transport chain, also known as the electron transport system, is a group of proteins that transfer electrons through a membrane within mitochondria to create a gradient of protons that drives adenosine triphosphate (ATP)synthesis. The cell uses ATP as an energy source for metabolic processes and cellular functions. ETC involves series of reactions that convert redox energy from NADH (nicotinamide adenine dinucleotide (NAD) + hydrogen (H)) and FADH2(flavin adenine dinucleotide (FAD)) oxidation into proton-motive force(PMF), which is then used to synthesize ATP through conformational changes in the ATP synthase complex, a process known as oxidative phosphorylation.
Metabolism
Picture a campfire. It keeps the body warm on a cold night and provides light. To ensure that the fire keeps burning, fuel needs to be added(pieces of wood in this case). When a small piece is added, the fire burns bright for a bit and then dies down unless more wood is added. But, if too many pieces are placed at a time, the fire escalates and burns for a longer time, without actually burning away all the pieces that have been added. Many of them, especially the larger chunks or damp pieces, remain unburnt.
Cellular Respiration
Cellular respiration is the cellular process involved in the generation of adenosine triphosphate (ATP) molecules from the organic nutritional source obtained from the diet. It is a universal process observed in all types of life forms. The glucose (chemical formula C6H12O6) molecules are the preferred raw material for cell respiration as it possesses a simple structure and is highly efficient in nature.
![Homework 1
(a) The kinetic data given below are for the reaction catalyzed
by prostaglandin endoperoxide synthase. Focusing here on
the first two columns, determine the Vmax and Km of the
enzyme.
(b) Ibuprofen is an inhibitor of prostaglandin endoperoxide
synthase. By inhibiting the synthesis of prostaglandins,
ibuprofen reduces inflammation and pain. Us ing the data in
the first and third columns of the table, determine the type of
inhibition that ibuprofen exerts on prostaglandin
endoperoxi'
Rate of formation
[Arachidonic
acid]
(mm)
Rate of formation
of PGG2
(mm/min)
of PGG, with 10
mg/mL ibuprofen
(mM/min)
0.5
23.5
16.67
1.0
32.2
25.25
1.5
36.9
30.49
41.8
44.0
2.5
37.04
3.5
38.91](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fd6ee5bde-d510-41c6-b5c1-3f2131ac6fa9%2F7d43489e-5f54-4306-beb2-511cdf08f001%2Fwh6bwq_processed.jpeg&w=3840&q=75)
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