A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30-µg netilmicin disks [6]. Each laboratory tested three standard control strains on a different lot of Mueller-Hinton agar, with 150 tests performed per laboratory. For protocol control, each laboratory also performed 15 additional tests on eachof the control strains using the same lot of Mueller-Hinton agar across laboratories. The mean zone diameters for each of the nine laboratories are given in Table 6.11. *6.20 Provide a point and interval estimate (95% CI) for the interlaboratory standard deviation of mean zone diameters for each type of control strain, assuming each laboratory uses different media to perform the susceptibility tests. *6.21 Answer Problem 6.20 assuming each laboratory uses a common medium to perform the susceptibility tests. 6.22 Are there any advantages to using a common medium versus using different media for performing the susceptibility tests with regard to standardization of results across laboratories?
A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30-µg netilmicin disks [6]. Each laboratory tested three standard control strains on a different lot of Mueller-Hinton agar, with 150 tests performed per laboratory. For protocol control, each laboratory also performed 15 additional tests on eachof the control strains using the same lot of Mueller-Hinton agar across laboratories. The mean zone diameters for each of the nine laboratories are given in Table 6.11. *6.20 Provide a point and interval estimate (95% CI) for the interlaboratory standard deviation of mean zone diameters for each type of control strain, assuming each laboratory uses different media to perform the susceptibility tests. *6.21 Answer Problem 6.20 assuming each laboratory uses a common medium to perform the susceptibility tests. 6.22 Are there any advantages to using a common medium versus using different media for performing the susceptibility tests with regard to standardization of results across laboratories?
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
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A nine-laboratory cooperative study was performed to evaluate quality control for susceptibility tests with 30-µg netilmicin disks [6]. Each laboratory tested three standard control strains on a different lot of Mueller-Hinton agar, with 150 tests performed per laboratory. For protocol control, each laboratory also performed 15 additional tests on eachof the control strains using the same lot of Mueller-Hinton agar across laboratories. The mean zone diameters for each of the nine laboratories are given in Table 6.11.
*6.20 Provide a point and interval estimate (95% CI) for the interlaboratory standard deviation of mean zone diameters for each type of control strain, assuming each laboratory uses different media to perform the susceptibility tests.
*6.21 Answer Problem 6.20 assuming each laboratory uses a common medium to perform the susceptibility tests.
6.22 Are there any advantages to using a common medium versus using different media for performing the susceptibility tests with regard to standardization of results across laboratories?
Transcribed Image Text:TABLE 6.11
Mean zone diameters with 30-ug netilmicin disks tested in nine separate laboratories
Type of control strain
E. coli
S. aureus
P. aeruginosa
Laboratory
Different media
Common medium
Different media
Common medium
Different media
Common medium
A
27.5
23.8
25.4
23.9
20.1
16.7
B
24.6
21.1
24.8
24.2
18.4
17.0
25.3
25.4
24.6
25.0
16.8
17.1
D
28.7
25.4
29.8
26.7
21.7
18.2
E
23.0
24.8
27.5
25.3
20.1
16.7
F
26.8
25.7
28.1
25.2
20.3
19.2
G
24.7
26.8
31.2
27.1
22.8
18.8
24.3
26.2
24.3
26.5
19.9
18.1
24.9
26.3
25.4
25.1
19.3
19.2
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